CATH Superfamily 2.20.25.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Probable Transcription elongation factor S-II
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
26 |
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P07273 (/IPI)
P10711 (/IPI)
P10711 (/IPI)
(16 more) |
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
8 | P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) P07273 (/IPI) |
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
RNA polymerase II complex recruiting activity GO:0001139
Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q54YG9 (/ISS) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Transcription-coupled nucleotide-excision repair GO:0006283
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
|
11 |
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
(1 more) |
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
11 |
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
(1 more) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
11 |
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
(1 more) |
Maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter GO:0001193
Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
|
8 | P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) |
Maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter GO:0001193
Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
Transcription elongation from RNA polymerase I promoter GO:0006362
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
8 | P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) |
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
|
8 | P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) P07273 (/IGI) |
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
Transcription antitermination GO:0031564
Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s).
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
TRNA transcription by RNA polymerase III GO:0042797
The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899
Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
|
8 | P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) P07273 (/IDA) |
Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899
Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
|
8 | P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) P07273 (/IMP) |
DNA-templated transcription, elongation GO:0006354
The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
|
4 | Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) |
Regulation of DNA-templated transcription, elongation GO:0032784
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
|
4 | Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
3 | P20232 (/ISS) P20232 (/ISS) Q54YG9 (/ISS) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P10711 (/IDA) P10711 (/IDA) Q63799 (/IDA) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8IBV2 (/ISS) Q8IBV2 (/ISS) |
Response to gibberellin GO:0009739
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus.
|
2 | Q9ZVH8 (/IMP) Q9ZVH8 (/IMP) |
Seed germination GO:0009845
The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis.
|
2 | Q9ZVH8 (/IMP) Q9ZVH8 (/IMP) |
Negative regulation of flower development GO:0009910
Any process that stops, prevents, or reduces the frequency, rate or extent of flower development.
|
2 | Q9ZVH8 (/IMP) Q9ZVH8 (/IMP) |
Seed dormancy process GO:0010162
A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors.
|
2 | Q9ZVH8 (/IMP) Q9ZVH8 (/IMP) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | P10711 (/IMP) P10711 (/IMP) |
Regulation of DNA-templated transcription, elongation GO:0032784
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
|
2 | Q8IBV2 (/ISS) Q8IBV2 (/ISS) |
Regulation of transcription elongation from RNA polymerase II promoter GO:0034243
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
2 | Q9ZVH8 (/IMP) Q9ZVH8 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P10711 (/IDA) P10711 (/IDA) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q9QVN7 (/ISO) Q9QVN7 (/ISO) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
1 | P49373 (/ISO) |
MRNA cleavage GO:0006379
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
|
1 | P49373 (/ISO) |
Positive regulation of exoribonuclease activity GO:1901919
Any process that activates or increases the frequency, rate or extent of exoribonuclease activity.
|
1 | Q4KLL0 (/IDA) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
22 |
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P07273 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
(12 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
P23193 (/TAS)
(1 more) |
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
11 |
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
(1 more) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
11 |
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
P23193 (/IDA)
(1 more) |
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
4 | Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) Q15560 (/NAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P20232 (/ISS) P20232 (/ISS) Q54YG9 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P10711 (/ISO) P10711 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P10711 (/IDA) P10711 (/IDA) |
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
|
2 | P10711 (/ISO) P10711 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | P10711 (/ISO) P10711 (/ISO) |
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
2 | Q8IBV2 (/ISS) Q8IBV2 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P49373 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q63799 (/TAS) |