The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Tie2 ligand-binding domain superfamily
".
FunFam 86: Cell death abnormality protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
|
1 | Q9XWD6 (/IPI) |
|
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
|
1 | Q9XWD6 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9XWD6 (/IPI) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | Q9XWD6 (/IGI) |
|
Phagolysosome assembly GO:0001845
The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
|
1 | Q9XWD6 (/IMP) |
|
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
|
1 | Q9XWD6 (/IMP) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q9XWD6 (/IDA) |
|
Cellular response to unfolded protein GO:0034620
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
|
1 | Q9XWD6 (/IDA) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
1 | Q9XWD6 (/IMP) |
|
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
|
1 | Q9XWD6 (/IDA) |
|
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
|
1 | Q9XWD6 (/IMP) |
|
Recognition of apoptotic cell GO:0043654
The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.
|
1 | Q9XWD6 (/IDA) |
|
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
1 | Q9XWD6 (/IDA) |
|
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
|
1 | Q9XWD6 (/IGI) |
|
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | Q9XWD6 (/IGI) |
|
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | Q9XWD6 (/IMP) |
|
Apoptotic process involved in development GO:1902742
Any apoptotic process that is involved in anatomical structure development.
|
1 | Q9XWD6 (/IGI) |
|
Apoptotic process involved in development GO:1902742
Any apoptotic process that is involved in anatomical structure development.
|
1 | Q9XWD6 (/IMP) |
|
Positive regulation of distal tip cell migration GO:1903356
Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
|
1 | Q9XWD6 (/IGI) |
|
Positive regulation of distal tip cell migration GO:1903356
Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
|
1 | Q9XWD6 (/IMP) |
|
Positive regulation of apoptotic process involved in development GO:1904747
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.
|
1 | Q9XWD6 (/IGI) |
|
Positive regulation of apoptotic process involved in development GO:1904747
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.
|
1 | Q9XWD6 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
1 | Q9XWD6 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9XWD6 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q9XWD6 (/IDA) |
|
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
|
1 | Q9XWD6 (/IDA) |
|
Pseudopodium membrane GO:0031260
The portion of the plasma membrane surrounding a pseudopodium.
|
1 | Q9XWD6 (/IDA) |