The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Tie2 ligand-binding domain superfamily
".
FunFam 4: Laminin subunit beta 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
5 | P02469 (/RCA) P07942 (/RCA) P55268 (/RCA) P55268 (/RCA) Q61292 (/RCA) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
4 | P02469 (/ISS) P07942 (/ISS) P55268 (/ISS) P55268 (/ISS) |
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
3 | P07942 (/NAS) P55268 (/NAS) P55268 (/NAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P02469 (/IPI) P07942 (/IPI) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | P02469 (/IMP) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | Q61292 (/IPI) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | P07942 (/IDA) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | P02469 (/ISO) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P02469 (/IPI) |
Glycosphingolipid binding GO:0043208
Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
|
1 | P02469 (/IDA) |
There are 53 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
4 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) B7ZDA6 (/IMP) Q8JHV7 (/IMP) |
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Determination of left/right asymmetry in lateral mesoderm GO:0003140
The establishment of the lateral mesoderm with respect to the left and right halves.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Optokinetic behavior GO:0007634
The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
3 | P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) |
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
3 | P02469 (/IDA) P07942 (/IDA) Q61292 (/IDA) |
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
3 | P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
3 | P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) |
Eye morphogenesis GO:0048592
The process in which the anatomical structures of the eye are generated and organized.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Hypochord development GO:0055016
The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Regulation of cilium assembly GO:1902017
Any process that modulates the frequency, rate or extent of cilium assembly.
|
3 | A0A0R4IDN1 (/IMP) A0A0R4IY30 (/IMP) Q8JHV7 (/IMP) |
Cell morphogenesis involved in differentiation GO:0000904
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
|
1 | Q61292 (/IGI) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P07942 (/TAS) |
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
|
1 | P02469 (/IDA) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q61292 (/IGI) |
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
1 | Q61292 (/IMP) |
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
|
1 | P02469 (/IMP) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
1 | Q61292 (/IGI) |
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
1 | P02469 (/NAS) |
Astrocyte development GO:0014002
The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
|
1 | Q61292 (/IGI) |
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
|
1 | Q61292 (/IDA) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
1 | B7ZDA6 (/IMP) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | P02469 (/IMP) |
Neuronal-glial interaction involved in cerebral cortex radial glia guided migration GO:0021812
The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
|
1 | P07942 (/IMP) |
Neuronal-glial interaction involved in cerebral cortex radial glia guided migration GO:0021812
The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
|
1 | P02469 (/ISO) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P07942 (/IDA) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P02469 (/ISO) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P02469 (/ISS) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P02469 (/ISO) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P02469 (/ISS) |
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
1 | P07942 (/IDA) |
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
1 | P02469 (/ISO) |
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
|
1 | P07942 (/IEP) |
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
|
1 | O44565 (/IMP) |
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
|
1 | P07942 (/IDA) |
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
|
1 | P02469 (/ISO) |
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
|
1 | P02469 (/ISS) |
Axon extension involved in regeneration GO:0048677
Long distance growth of a single axon process involved in regeneration of the neuron.
|
1 | Q61292 (/IMP) |
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
1 | P07942 (/TAS) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
1 | Q61292 (/IMP) |
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
1 | Q61292 (/IGI) |
Pharynx development GO:0060465
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
|
1 | O44565 (/IMP) |
Basement membrane assembly GO:0070831
The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.
|
1 | B7ZDA6 (/IMP) |
Metanephric glomerular visceral epithelial cell development GO:0072249
The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros.
|
1 | Q61292 (/IMP) |
Metanephric glomerular basement membrane development GO:0072274
The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.
|
1 | Q61292 (/IMP) |
There are 42 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
6 | O44565 (/IDA) P02469 (/IDA) P07942 (/IDA) P55268 (/IDA) P55268 (/IDA) Q61292 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | P02469 (/TAS) P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) Q61292 (/TAS) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
5 | P02469 (/HDA) P07942 (/HDA) P55268 (/HDA) P55268 (/HDA) Q61292 (/HDA) |
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
3 | P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
3 | P07942 (/TAS) P55268 (/TAS) P55268 (/TAS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
3 | P07942 (/HDA) P55268 (/HDA) P55268 (/HDA) |
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
2 | P02469 (/ISO) Q61292 (/ISO) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
2 | P02469 (/IDA) P07942 (/IDA) |
Laminin-3 complex GO:0005608
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
|
2 | P55268 (/IPI) P55268 (/IPI) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P02469 (/HDA) Q61292 (/HDA) |
Laminin complex GO:0043256
A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.
|
2 | P02469 (/IDA) Q61292 (/IDA) |
Laminin-11 complex GO:0043260
A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.
|
2 | P55268 (/TAS) P55268 (/TAS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P07942 (/ISS) Q8JHV7 (/ISS) |
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | P02469 (/ISS) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/IPI) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISO) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISS) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/TAS) |
Laminin-2 complex GO:0005607
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/IDA) |
Laminin-2 complex GO:0005607
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISO) |
Laminin-2 complex GO:0005607
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISS) |
Laminin-2 complex GO:0005607
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/TAS) |
Laminin-3 complex GO:0005608
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
|
1 | Q61292 (/IDA) |
Laminin-3 complex GO:0005608
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
|
1 | Q61292 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P07942 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P02469 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P02469 (/IDA) |
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
|
1 | P02469 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
1 | Q61292 (/IDA) |
Synaptic cleft GO:0043083
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
|
1 | Q61292 (/IDA) |
Laminin-8 complex GO:0043257
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/IDA) |
Laminin-8 complex GO:0043257
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISO) |
Laminin-8 complex GO:0043257
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISS) |
Laminin-8 complex GO:0043257
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/TAS) |
Laminin-10 complex GO:0043259
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
|
1 | P07942 (/IDA) |
Laminin-10 complex GO:0043259
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/IPI) |
Laminin-10 complex GO:0043259
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISO) |
Laminin-10 complex GO:0043259
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
|
1 | P02469 (/ISS) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | Q61292 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | P02469 (/IDA) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
1 | D3ZQN7 (/IDA) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
1 | P02469 (/ISO) |