The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tie2 ligand-binding domain superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Multiple epidermal growth factor-like domains 10

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
2 Q6DIB5 (/IPI) Q96KG7 (/IPI)
Complement component C1q binding GO:0001849
Interacting selectively and non-covalently with the C1q component of the classical complement cascade.
1 Q96KG7 (/IDA)
Complement component C1q binding GO:0001849
Interacting selectively and non-covalently with the C1q component of the classical complement cascade.
1 Q6DIB5 (/ISO)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
1 Q96KG7 (/IDA)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
1 Q6DIB5 (/ISO)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
1 Q6DIB5 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Skeletal muscle satellite cell differentiation GO:0014816
The process in which a relatively unspecialized cell acquires specialized features of a satellite cell.
2 Q6DIB5 (/IMP) Q96KG7 (/IMP)
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 Q6DIB5 (/IMP) Q96KG7 (/IMP)
Skeletal muscle satellite cell activation GO:0014719
The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
1 Q6DIB5 (/IMP)
Skeletal muscle satellite cell activation GO:0014719
The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
1 Q96KG7 (/ISS)
Skeletal muscle satellite cell differentiation GO:0014816
The process in which a relatively unspecialized cell acquires specialized features of a satellite cell.
1 Q6DIB5 (/ISO)
Skeletal muscle satellite cell proliferation GO:0014841
The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
1 Q6DIB5 (/IDA)
Skeletal muscle satellite cell proliferation GO:0014841
The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
1 Q96KG7 (/ISS)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
1 A0A2R8QIB3 (/IMP)
Muscle cell proliferation GO:0033002
The expansion of a muscle cell population by cell division.
1 Q96KG7 (/IMP)
Muscle cell proliferation GO:0033002
The expansion of a muscle cell population by cell division.
1 Q6DIB5 (/ISO)
Homotypic cell-cell adhesion GO:0034109
The attachment of a cell to a second cell of the identical type via adhesion molecules.
1 Q96KG7 (/IDA)
Homotypic cell-cell adhesion GO:0034109
The attachment of a cell to a second cell of the identical type via adhesion molecules.
1 Q6DIB5 (/ISO)
Homotypic cell-cell adhesion GO:0034109
The attachment of a cell to a second cell of the identical type via adhesion molecules.
1 Q6DIB5 (/ISS)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 F1MAP4 (/NAS)
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
1 Q6DIB5 (/IMP)
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
1 Q96KG7 (/ISS)
Recognition of apoptotic cell GO:0043654
The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.
1 Q6DIB5 (/IDA)
Recognition of apoptotic cell GO:0043654
The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.
1 Q6DIB5 (/IMP)
Regulation of skeletal muscle tissue development GO:0048641
Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.
1 Q96KG7 (/IMP)
Regulation of skeletal muscle tissue development GO:0048641
Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.
1 Q6DIB5 (/ISO)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
1 Q96KG7 (/IMP)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
1 Q6DIB5 (/ISO)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
1 Q6DIB5 (/ISS)
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q6DIB5 (/ISO)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 Q96KG7 (/IMP)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 Q6DIB5 (/ISO)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 Q6DIB5 (/ISS)
Apoptotic process involved in development GO:1902742
Any apoptotic process that is involved in anatomical structure development.
1 Q6DIB5 (/IMP)
Apoptotic process involved in development GO:1902742
Any apoptotic process that is involved in anatomical structure development.
1 Q96KG7 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
2 Q6DIB5 (/IDA) Q96KG7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q6DIB5 (/IDA) Q96KG7 (/IDA)
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
1 Q6DIB5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q6DIB5 (/ISO)