The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 56: Histone-lysine N-methyltransferase, H3 lysine-4 sp...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P38827 (/IDA) P38827 (/IDA) P38827 (/IDA) P38827 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P38827 (/IPI) P38827 (/IPI) P38827 (/IPI) P38827 (/IPI)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
4 P38827 (/IGI) P38827 (/IGI) P38827 (/IGI) P38827 (/IGI)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
2 Q54HS3 (/IMP) Q5ABG1 (/IMP)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
5 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) Q5ABG1 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
4 P38827 (/IGI) P38827 (/IGI) P38827 (/IGI) P38827 (/IGI)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
4 P38827 (/IPI) P38827 (/IPI) P38827 (/IPI) P38827 (/IPI)
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
4 P38827 (/IGI) P38827 (/IGI) P38827 (/IGI) P38827 (/IGI)
Regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
4 P38827 (/IGI) P38827 (/IGI) P38827 (/IGI) P38827 (/IGI)
Regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Histone H3-K4 dimethylation GO:0044648
The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
4 P38827 (/IDA) P38827 (/IDA) P38827 (/IDA) P38827 (/IDA)
Histone H3-K4 trimethylation GO:0080182
The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Regulation of chromatin organization GO:1902275
Any process that modulates the frequency, rate or extent of chromatin organization.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Regulation of meiotic DNA double-strand break formation GO:1903341
Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation.
4 P38827 (/IMP) P38827 (/IMP) P38827 (/IMP) P38827 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q5ABG1 (/IMP)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q54HS3 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5ABG1 (/IMP)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
1 Q54HS3 (/IMP)
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
1 Q5ABG1 (/IMP)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
1 Q54HS3 (/IMP)
Induction by symbiont of host defense response GO:0044416
The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q5ABG1 (/IDA)
Cellular developmental process GO:0048869
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
1 Q5ABG1 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
4 P38827 (/IGI) P38827 (/IGI) P38827 (/IGI) P38827 (/IGI)
Set1C/COMPASS complex GO:0048188
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
4 P38827 (/IPI) P38827 (/IPI) P38827 (/IPI) P38827 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q54HS3 (/IC)
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