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CATH Superfamily 2.140.10.30

Dipeptidylpeptidase IV, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dipeptidylpeptidase IV, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Dipeptidyl peptidase 4

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dipeptidyl-peptidase IV. [EC: 3.4.14.5]
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
  • A membrane-bound serine-type peptidase in mammals.
  • EC 3.4.14.11 catalyzes a similar reaction.
  • Belongs to peptidase family S9B.
 20 A0A480UDQ9 A0A480UDQ9 A5D7B7 G3RGI5 G3RGI5 G3RGI5 H2QIW2 H2QIW2 H2QIW2 P14740
(10 more...)
Prolyl oligopeptidase. [EC: 3.4.21.26]
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
  • Found in vertebrates, plants and Flavobacterium.
  • Generally cytosolic, commonly activated by thiol compounds.
  • Belongs to peptidase family S9A.
  • Formerly EC 3.4.22.18.
 11 A5D7B7 G3RGI5 G3RGI5 G3RGI5 H2QIW2 H2QIW2 H2QIW2 P97321 Q12884 Q12884
(1 more...)
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