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CATH Superfamily 2.140.10.10

Quinoprotein alcohol dehydrogenase-like superfamily

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Quinoprotein alcohol dehydrogenase-like superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Quinoprotein glucose dehydrogenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Quinoprotein glucose dehydrogenase (PQQ, quinone). [EC: 1.1.5.2]
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.
  • Integral membrane protein containing PQQ as prosthetic group.
  • It also contains bound ubiquinone and Mg(2+) or Ca(2+).
  • Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate.
  • Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure.
  • It occurs in a wide range of bacteria.
  • Catalyzes a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm.
  • Oxidizes other monosaccharides including the pyranose forms of pentoses.
  • Formerly EC 1.1.99.17.
 756 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7 A0A037Y8H7
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