The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

Any process in which a protein is transported to, or maintained at, the kinetochore.

Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.

Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.

Any process in which a protein is transported to, or maintained at, the kinetochore.

Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

Any process that modulates the frequency, rate or extent of chromosome separation.

That part of the nuclear content other than the chromosomes or the nucleolus.

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

That part of the nuclear content other than the chromosomes or the nucleolus.

Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.

A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.