The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Multiple epidermal growth factor-like domains 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q7Z7M0 (/IPI)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Embryonic heart tube left/right pattern formation GO:0060971
The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Determination of digestive tract left/right asymmetry GO:0071907
Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Left/right pattern formation GO:0060972
The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
15 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(5 more)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
15 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(5 more)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
2 Q7Z7M0 (/ISS) Q9QYP0 (/ISS)
Left/right pattern formation GO:0060972
The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
2 P60882 (/IMP) Q7Z7M0 (/IMP)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
2 P60882 (/IMP) Q7Z7M0 (/IMP)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
1 P60882 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 P60882 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P60882 (/IMP)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
1 P60882 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P60882 (/IGI)
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
1 Q7Z7M0 (/IMP)
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
1 P60882 (/ISO)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
1 Q7Z7M0 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
1 P60882 (/ISO)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
1 P60882 (/IMP)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
1 P60882 (/IMP)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
1 P60882 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
1 Q7Z7M0 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
1 P60882 (/ISO)
Embryonic heart tube left/right pattern formation GO:0060971
The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place.
1 P60882 (/IMP)
Left/right pattern formation GO:0060972
The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
1 P60882 (/ISO)
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
1 P60882 (/IMP)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
1 P60882 (/ISO)
Determination of digestive tract left/right asymmetry GO:0071907
Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.
1 P60882 (/IMP)
Craniofacial suture morphogenesis GO:0097094
The process in which any suture between cranial and/or facial bones is generated and organized.
1 Q7Z7M0 (/IMP)
Craniofacial suture morphogenesis GO:0097094
The process in which any suture between cranial and/or facial bones is generated and organized.
1 P60882 (/ISO)
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
1 P60882 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 E2RM39 (/ISS) F1RGK2 (/ISS) F7GCA4 (/ISS) G1PV93 (/ISS) G1TF43 (/ISS) G3QEP8 (/ISS) G5AZR7 (/ISS) G7NLL7 (/ISS) G7PXR3 (/ISS) H0VMP5 (/ISS)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P60882 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q7Z7M0 (/HDA)
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