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CATH Superfamily 2.120.10.80

Kelch-type beta propeller

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 246: tRNA wybutosine-synthesizing protein 4

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)- methoxycarbonyltransferase. [EC: 2.3.1.231]
S-adenosyl-L-methionine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) = S-adenosyl-L- homocysteine + wybutosine(37) in tRNA(Phe).
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.1.1.290.
 4 A0A1H6PZI0 A0A1H6PZI0 Q6C3P4 Q6C3P4
TRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase. [EC: 2.1.1.290]
S-adenosyl-L-methionine + 7-((3S)-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe).
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.3.1.231.
 4 A0A1H6PZI0 A0A1H6PZI0 Q6C3P4 Q6C3P4
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