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CATH Superfamily 2.120.10.80

Kelch-type beta propeller

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 122: tRNA wybutosine-synthesizing protein 2/3/4

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase. [EC: 2.5.1.114]
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) = S-methyl- 5'-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe).
  • The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases.
  • This modification is essential for translational reading-frame maintenance.
  • The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).
 1 Q8H4D4
TRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))- methyltransferase. [EC: 2.1.1.282]
S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4- demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)- (3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).
  • The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs.
  • These modifications are important for translational reading-frame maintenance.
  • The enzyme is found in all eukaryotes and in some archaea, but not in bacteria.
  • The eukaryotic enzyme is involved in the biosynthesis of wybutosine.
 1 Q8H4D4
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