The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"TolB, C-terminal domain
".
FunFam 6: Teneurin transmembrane protein 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | Q6N022 (/ISS) Q9UKZ4 (/ISS) Q9W6V6 (/ISS) Q9W7R3 (/ISS) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q3UHK6 (/IDA) Q9WTS4 (/IDA) Q9WTS4 (/IDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) Q9W7R3 (/ISS) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9WTS4 (/IDA) Q9WTS4 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9W6V6 (/IPI) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q9UKZ4 (/TAS) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
|
3 | Q3UHK6 (/ISS) Q6N022 (/ISS) Q9W7R3 (/ISS) |
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Regulation of transcription by RNA polymerase III GO:0006359
Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
2 | Q3UHK6 (/ISS) Q9W7R3 (/ISS) |
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
2 | Q6N022 (/ISS) Q9W7R3 (/ISS) |
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
|
2 | Q3UHK6 (/IMP) Q6N022 (/IMP) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | Q3UHK6 (/ISS) Q9W7R3 (/ISS) |
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
2 | Q6N022 (/ISS) Q9W7R3 (/ISS) |
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Positive regulation of gastrulation GO:2000543
Any process that activates or increases the frequency, rate or extent of gastrulation.
|
2 | Q6N022 (/ISS) Q9W7R3 (/ISS) |
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
|
1 | Q3UHK6 (/IMP) |
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | Q9UKZ4 (/TAS) |
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
|
1 | Q9W7R3 (/ISS) |
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | Q9UKZ4 (/TAS) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q9W7R3 (/IMP) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q9UKZ4 (/TAS) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q9W7R3 (/ISS) |
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
1 | Q6N022 (/IMP) |
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
1 | Q3UHK6 (/ISO) |
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
1 | Q3UHK6 (/IMP) |
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
|
1 | Q3UHK6 (/ISO) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
1 | Q6N022 (/IMP) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
1 | Q3UHK6 (/ISO) |
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
1 | Q3UHK6 (/IMP) |
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
|
1 | Q3UHK6 (/IMP) |
Cardiac cell fate specification GO:0060912
The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
|
1 | Q3UHK6 (/IMP) |
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
|
1 | Q9W6V6 (/IDA) |
Positive regulation of gastrulation GO:2000543
Any process that activates or increases the frequency, rate or extent of gastrulation.
|
1 | Q3UHK6 (/IMP) |
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q6N022 (/ISS) Q9UKZ4 (/ISS) Q9W7R3 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q6N022 (/ISS) Q9UKZ4 (/ISS) Q9W7R3 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | Q3UHK6 (/ISS) Q9UKZ4 (/ISS) Q9W7R3 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q6N022 (/IDA) Q9W6V6 (/IDA) Q9WTS4 (/IDA) Q9WTS4 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q3UHK6 (/IDA) Q9WTS4 (/IDA) Q9WTS4 (/IDA) |
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
3 | Q9UKZ4 (/ISS) Q9WTS4 (/ISS) Q9WTS4 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q3UHK6 (/IDA) Q9W6V6 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q3UHK6 (/IDA) Q9W6V6 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | Q6N022 (/ISS) Q9W7R3 (/ISS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | Q9UKZ4 (/ISS) Q9W6V6 (/ISS) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q9UKZ4 (/TAS) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q9W6V6 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q9W6V6 (/IDA) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | Q9W6V6 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q3UHK6 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9W7R3 (/ISS) |
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q9W6V6 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q9W6V6 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q3UHK6 (/IDA) |