The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TolB, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Tyrosine-protein kinase receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 P08941 (/ISS) Q63132 (/ISS) Q78DX7 (/ISS)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
2 P08922 (/IPI) Q78DX7 (/IPI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P08922 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q78DX7 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P08922 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 Q78DX7 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
3 P08941 (/ISS) Q63132 (/ISS) Q78DX7 (/ISS)
Columnar/cuboidal epithelial cell development GO:0002066
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
3 P08922 (/ISS) P08941 (/ISS) Q63132 (/ISS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 P08922 (/ISS) P08941 (/ISS) Q63132 (/ISS)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
3 P08922 (/ISS) P08941 (/ISS) Q63132 (/ISS)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
3 P08941 (/ISS) Q63132 (/ISS) Q78DX7 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 P08922 (/ISS) P08941 (/ISS) Q63132 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P08922 (/IDA) Q78DX7 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P08941 (/ISS) Q63132 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 P08922 (/ISS) Q63132 (/ISS)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 P08922 (/IDA)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 Q78DX7 (/ISO)
Columnar/cuboidal epithelial cell development GO:0002066
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
1 Q78DX7 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q78DX7 (/ISO)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q78DX7 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q78DX7 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q78DX7 (/IMP)
Regulation of phosphate transport GO:0010966
Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q78DX7 (/IMP)
Signal transduction by protein phosphorylation GO:0023014
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
1 Q78DX7 (/IDA)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q78DX7 (/IDA)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
1 P08922 (/IDA)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
1 Q78DX7 (/ISO)
Peptidyl-tyrosine autophosphorylation GO:0038083
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
1 Q78DX7 (/IDA)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q78DX7 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q78DX7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P08922 (/TAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q78DX7 (/IDA)
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