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CATH Superfamily 2.120.10.30

TolB, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TolB, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Serum paraoxonase/arylesterase 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Arylesterase. [EC: 3.1.1.2]
A phenyl acetate + H(2)O = a phenol + acetate.
  • Acts on many phenolic esters.
  • It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases.
  • The natural substrates of the paraoxonases are lactones, with (+-)-5- hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate.
 30 A0A0J9YYG4 A0A0J9YYG4 A0A0J9YYG4 A0A2I3SMF6 A0A2I3SMF6 A0A2I3SMF6 A0A2J8L4C5 A0A2J8L4C5 A0A2J8L4C5 A0A2R9AP95
(20 more...)
Quorum-quenching N-acyl-homoserine lactonase. [EC: 3.1.1.81]
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
 28 A0A0J9YYG4 A0A0J9YYG4 A0A0J9YYG4 A0A2I3SMF6 A0A2I3SMF6 A0A2I3SMF6 A0A2J8L4C5 A0A2J8L4C5 A0A2J8L4C5 A0A2R9AP95
(18 more...)
Aryldialkylphosphatase. [EC: 3.1.8.1]
An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
  • Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids.
  • Inhibited by chelating agents.
  • Previously regarded as identical with EC 3.1.1.2.
 17 A0A2I3SMF6 A0A2I3SMF6 A0A2I3SMF6 A0A2R9AP95 A0A2R9AP95 A0A2R9AP95 P27169 P27170 P52430 P55159
(7 more...)
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