The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rieske [2Fe-2S] iron-sulphur domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Methylxanthine N1-demethylase NdmA

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylxanthine N(3)-demethylase. [EC: 1.14.13.179]
(1) Theobromine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde. (2) 3-methylxanthine + O(2) + NAD(P)H = xanthine + NAD(P)(+) + H(2)O + formaldehyde.
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, and has higher activity with NADH than with NADPH.
  • Also demethylates caffeine and theophylline with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
4 A0A0M3CMC5 A0A0M3CMC5 H9N290 H9N290
Methylxanthine N(1)-demethylase. [EC: 1.14.13.178]
(1) Caffeine + O(2) + NAD(P)H = theobromine + NAD(P)(+) + H(2)O + formaldehyde. (2) Theophylline + O(2) + NAD(P)H = 3-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde. (3) Paraxanthine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde.
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold higher activity with NADH than with NADPH.
  • Also demethylate 1-methylxantine with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
4 A0A0M3CP22 A0A0M3CP22 H9N289 H9N289
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