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CATH Superfamily 2.102.10.10

Rieske [2Fe-2S] iron-sulphur domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rieske [2Fe-2S] iron-sulphur domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: Cholesterol 7-desaturase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cholesterol 7-desaturase. [EC: 1.14.19.21]
Cholesterol + O(2) + NAD(P)H = cholesta-5,7-dien-3-beta-ol + NAD(P)(+) + 2 H(2)O.
  • The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase.
  • In insects it participates in the the biosythesis of ecdysteroid hormones.
  • The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin.
  • The enzyme differs from regular desaturases, such as EC 1.14.19.20, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.
 1 Q17938
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