The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78: Complement decay-accelerating factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
3 A0A0G2QC50 (/IDA) Q9Z0L9 (/IDA) Q9Z0M0 (/IDA)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
2 Q61475 (/ISO) Q61476 (/ISO)
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
2 Q61475 (/ISO) Q61476 (/ISO)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 Q61475 (/ISO) Q61476 (/ISO)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
1 P08174 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P08174 (/IPI)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P08174 (/IDA)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
4 A0A0G2QC50 (/IDA) P08174 (/IDA) Q9Z0L9 (/IDA) Q9Z0M0 (/IDA)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
4 P49457 (/ISS) Q60401 (/ISS) Q61475 (/ISS) Q61476 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
3 A0A0G2QC50 (/IEP) Q9Z0L9 (/IEP) Q9Z0M0 (/IEP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 A0A0G2QC50 (/IEP) Q9Z0L9 (/IEP) Q9Z0M0 (/IEP)
Maternal process involved in parturition GO:0060137
A reproductive process occurring in the mother that results in birth.
3 A0A0G2QC50 (/IEP) Q9Z0L9 (/IEP) Q9Z0M0 (/IEP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
1 P08174 (/TAS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P08174 (/IDA)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 P08174 (/IDA)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 Q61475 (/ISO)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 P08174 (/TAS)
Regulation of complement activation, classical pathway GO:0030450
Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.
1 Q61475 (/IMP)
Regulation of lipopolysaccharide-mediated signaling pathway GO:0031664
Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
1 P08174 (/IDA)
CD4-positive, alpha-beta T cell cytokine production GO:0035743
Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell.
1 P08174 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P08174 (/TAS)
Respiratory burst GO:0045730
A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
1 P08174 (/NAS)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
1 P08174 (/IMP)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
1 P08174 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
1 Q61475 (/ISO)
Positive regulation of CD4-positive, alpha-beta T cell activation GO:2000516
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.
1 P08174 (/IDA)
Positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.
1 P08174 (/IDA)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sperm midpiece GO:0097225
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
4 F1S0J0 (/IDA) Q9GLM0 (/IDA) Q9GLM1 (/IDA) Q9GLM2 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 A0A0G2QC50 (/IDA) Q9Z0L9 (/IDA) Q9Z0M0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q61475 (/ISO) Q61476 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q61475 (/ISO) Q61476 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q61475 (/ISO) Q61476 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 Q61475 (/ISO) Q61476 (/ISO)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 P08174 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P08174 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P08174 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P08174 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q61475 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P08174 (/IDA)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 P08174 (/TAS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 P08174 (/TAS)
Endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
1 P08174 (/TAS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P08174 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P08174 (/HDA)
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
1 P08174 (/TAS)
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