The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Complement Module, domain 1
".
FunFam 69: Complement component receptor type 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P19070 (/IPI) P20023 (/IPI) |
|
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
|
1 | P20023 (/IDA) |
|
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
|
1 | P19070 (/ISO) |
|
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
|
1 | P17927 (/IDA) |
|
Complement component C4b binding GO:0001855
Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
|
1 | P17927 (/IDA) |
|
Complement component C4b receptor activity GO:0001861
Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P17927 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P20023 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P19070 (/ISO) |
|
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P19070 (/IMP) |
|
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P20023 (/NAS) |
|
Complement receptor activity GO:0004875
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P20023 (/TAS) |
|
Complement component C3b receptor activity GO:0004877
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P17927 (/IDA) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
1 | P20023 (/NAS) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | P19070 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P20023 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P19070 (/ISO) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
|
3 | P17927 (/TAS) P20023 (/TAS) Q64735 (/TAS) |
|
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
|
3 | Q63135 (/IMP) Q63135 (/IMP) Q64735 (/IMP) |
|
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | Q64735 (/IGI) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | P20023 (/NAS) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | P20023 (/IDA) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | P19070 (/ISO) |
|
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
|
1 | Q64735 (/IMP) |
|
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
|
1 | Q64735 (/ISO) |
|
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
|
1 | P20023 (/IDA) |
|
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
|
1 | P19070 (/ISO) |
|
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | P19070 (/IMP) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | P17927 (/TAS) |
|
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
|
1 | P17927 (/TAS) |
|
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
|
1 | Q64735 (/ISO) |
|
Negative regulation of complement activation, alternative pathway GO:0045957
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.
|
1 | P17927 (/IDA) |
|
Negative regulation of complement activation, classical pathway GO:0045959
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.
|
1 | P17927 (/IDA) |
|
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
|
1 | P17927 (/IDA) |
|
Positive regulation of serine-type endopeptidase activity GO:1900005
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
|
1 | P17927 (/IDA) |
|
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
|
1 | Q64735 (/ISO) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P17927 (/TAS) P20023 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | P19070 (/IDA) Q64735 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q29528 (/ISS) Q29530 (/ISS) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P19070 (/ISO) Q64735 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P17927 (/HDA) P20023 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P20023 (/NAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P17927 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P17927 (/IDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P20023 (/NAS) |
|
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
|
1 | P17927 (/TAS) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P20023 (/IDA) |
|
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
1 | P17927 (/TAS) |
