The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34: BMP-binding endothelial regulator protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 A0A0B5JK69 (/IPI) A0A0R4IDS8 (/IPI) A0A0R4IGC8 (/IPI) A0A0R4IIF4 (/IPI) A6H8K2 (/IPI) Q3U492 (/IPI) Q5D734 (/IPI) Q8CJ69 (/IPI)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
6 A0A0B5JK69 (/IDA) A0A0R4IDS8 (/IDA) A0A0R4IGC8 (/IDA) A0A0R4IIF4 (/IDA) A6H8K2 (/IDA) Q5D734 (/IDA)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 Q8CJ69 (/RCA)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
6 A0A0B5JK69 (/IGI) A0A0R4IDS8 (/IGI) A0A0R4IGC8 (/IGI) A0A0R4IIF4 (/IGI) A6H8K2 (/IGI) Q5D734 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
6 A0A0B5JK69 (/IGI) A0A0R4IDS8 (/IGI) A0A0R4IGC8 (/IGI) A0A0R4IIF4 (/IGI) A6H8K2 (/IGI) Q5D734 (/IGI)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Otic placode formation GO:0043049
The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.
6 A0A0B5JK69 (/IGI) A0A0R4IDS8 (/IGI) A0A0R4IGC8 (/IGI) A0A0R4IIF4 (/IGI) A6H8K2 (/IGI) Q5D734 (/IGI)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
6 A0A0B5JK69 (/IGI) A0A0R4IDS8 (/IGI) A0A0R4IGC8 (/IGI) A0A0R4IIF4 (/IGI) A6H8K2 (/IGI) Q5D734 (/IGI)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
6 A0A0B5JK69 (/IMP) A0A0R4IDS8 (/IMP) A0A0R4IGC8 (/IMP) A0A0R4IIF4 (/IMP) A6H8K2 (/IMP) Q5D734 (/IMP)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
2 Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
2 Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
2 Q8N8U9 (/TAS) Q8N8U9 (/TAS)
Endothelial cell activation GO:0042118
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2 Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Regulation of pathway-restricted SMAD protein phosphorylation GO:0060393
Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2 Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
2 Q8N8U9 (/IGI) Q8N8U9 (/IGI)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 Q8CJ69 (/IEP)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
1 Q8CJ69 (/ISO)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 Q3U492 (/IGI)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 Q8CJ69 (/ISO)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
1 Q3U492 (/IDA)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 Q8CJ69 (/IDA)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 Q643S1 (/ISS)
Endothelial cell activation GO:0042118
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q8CJ69 (/ISO)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
1 Q8CJ69 (/IDA)
Regulation of pathway-restricted SMAD protein phosphorylation GO:0060393
Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
1 Q8CJ69 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q8CJ69 (/ISO)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
1 Q8CJ69 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
9 A0A0B5JK69 (/IDA) A0A0R4IDS8 (/IDA) A0A0R4IGC8 (/IDA) A0A0R4IIF4 (/IDA) A6H8K2 (/IDA) Q3U492 (/IDA) Q5D734 (/IDA) Q8N8U9 (/IDA) Q8N8U9 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
6 A0A0B5JK69 (/IDA) A0A0R4IDS8 (/IDA) A0A0R4IGC8 (/IDA) A0A0R4IIF4 (/IDA) A6H8K2 (/IDA) Q5D734 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q8CJ69 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q643S1 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8CJ69 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8CJ69 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q3U515 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q8CJ69 (/HDA)
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