The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Complement inhibitory factor H

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
20 P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P08603 (/IPI) P08603 (/IPI)
(10 more)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
16 P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P08603 (/IDA) P08603 (/IDA)
(6 more)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
8 P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI) P06909 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
8 P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 P36980 (/IDA) Q03591 (/IDA) Q03591 (/IDA) Q9BXR6 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P36980 (/IDA) Q03591 (/IDA) Q03591 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 A0A0A6YXP6 (/ISO) Q61406 (/ISO) Q61406 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 A0A0A6YXP6 (/ISO) Q61406 (/ISO) Q61406 (/ISO)
Lipid transporter activity GO:0005319
Enables the directed movement of lipids into, out of or within a cell, or between cells.
2 Q92496 (/TAS) Q92496 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9BXR6 (/IMP)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
34 F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) G3V9R2 (/IDA) G3V9R2 (/IDA)
(24 more)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
26 F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) G3V9R2 (/IEP) G3V9R2 (/IEP)
(16 more)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
26 F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) G3V9R2 (/IEP) G3V9R2 (/IEP)
(16 more)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
26 F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) G3V9R2 (/IEP) G3V9R2 (/IEP)
(16 more)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
26 F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) F1M983 (/IEP) G3V9R2 (/IEP) G3V9R2 (/IEP)
(16 more)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
14 P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P36980 (/TAS) Q03591 (/TAS)
(4 more)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
10 P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) Q03591 (/TAS) Q03591 (/TAS)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
8 P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
8 P06909 (/IMP) P06909 (/IMP) P06909 (/IMP) P06909 (/IMP) P06909 (/IMP) P06909 (/IMP) P06909 (/IMP) P06909 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
8 P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA) P06909 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
8 P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA) P08603 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
4 P36980 (/IMP) Q03591 (/IMP) Q03591 (/IMP) Q9BXR6 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
3 P36980 (/IMP) Q03591 (/IMP) Q03591 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
3 A0A0A6YXP6 (/ISO) Q61406 (/ISO) Q61406 (/ISO)
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
3 A0A0A6YXP6 (/ISO) Q61406 (/ISO) Q61406 (/ISO)
Complement activation, alternative pathway GO:0006957
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
1 Q9BXR6 (/NAS)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q9BXR6 (/IDA)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
26 F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) G3V9R2 (/IDA) G3V9R2 (/IDA)
(16 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
26 F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) G3V9R2 (/IDA) G3V9R2 (/IDA)
(16 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
26 F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) G3V9R2 (/IDA) G3V9R2 (/IDA)
(16 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
26 F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) F1M983 (/IDA) G3V9R2 (/IDA) G3V9R2 (/IDA)
(16 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
14 P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P36980 (/TAS) Q03591 (/TAS)
(4 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
11 P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) P08603 (/TAS) Q02985 (/TAS) Q03591 (/TAS)
(1 more)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
11 P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) Q02985 (/HDA) Q03591 (/HDA)
(1 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
9 P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) P08603 (/HDA) Q02985 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 P06909 (/HDA) P06909 (/HDA) P06909 (/HDA) P06909 (/HDA) P06909 (/HDA) P06909 (/HDA) P06909 (/HDA) P06909 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO) P06909 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P36980 (/IDA) Q03591 (/IDA) Q03591 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 A0A0A6YXP6 (/ISO) Q61406 (/ISO) Q61406 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9BXR6 (/NAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9BXR6 (/IMP)
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