The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CD59
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: CD59 glycoprotein preproprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P13987 (/IPI) P13987 (/IPI)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
1 P27274 (/IDA)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
1 P58019 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of activation of membrane attack complex GO:0001971
Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
4 O55186 (/IDA) O55186 (/IDA) P27274 (/IDA) P58019 (/IDA)
Negative regulation of complement activation GO:0045916
Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
3 O55186 (/IDA) O55186 (/IDA) P58019 (/IDA)
Negative regulation of activation of membrane attack complex GO:0001971
Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
2 O55186 (/IMP) O55186 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
2 P13987 (/TAS) P13987 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P13987 (/TAS) P13987 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
2 P13987 (/TAS) P13987 (/TAS)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
2 O55186 (/IMP) O55186 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
2 P13987 (/IDA) P13987 (/IDA)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
2 O55186 (/ISO) O55186 (/ISO)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
2 P13987 (/TAS) P13987 (/TAS)
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
2 O55186 (/IMP) O55186 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P13987 (/TAS) P13987 (/TAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 O62680 (/IDA) O62680 (/IDA)
COPII vesicle coating GO:0048208
The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
2 P13987 (/TAS) P13987 (/TAS)
Negative regulation of fibroblast growth factor production GO:0090272
Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 O55186 (/IDA) O55186 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
2 P13987 (/IDA) P13987 (/IDA)
Regulation of complement-dependent cytotoxicity GO:1903659
Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
2 O55186 (/ISO) O55186 (/ISO)
Negative regulation of activation of membrane attack complex GO:0001971
Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
1 P58019 (/ISO)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
1 P27274 (/NAS)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P27274 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P58019 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P27274 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P58019 (/ISO)
Negative regulation of complement-dependent cytotoxicity GO:1903660
Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity.
1 P27274 (/IMP)
Negative regulation of complement-dependent cytotoxicity GO:1903660
Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity.
1 P58019 (/ISO)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 O55186 (/IDA) O55186 (/IDA) P13987 (/IDA) P13987 (/IDA) P58019 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O55186 (/IDA) O55186 (/IDA) P27274 (/IDA) P58019 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 P13987 (/TAS) P13987 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P13987 (/HDA) P13987 (/HDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P13987 (/TAS) P13987 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P13987 (/NAS) P13987 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P13987 (/TAS) P13987 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P13987 (/HDA) P13987 (/HDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 O55186 (/IDA) O55186 (/IDA)
ER to Golgi transport vesicle membrane GO:0012507
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
2 P13987 (/TAS) P13987 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P13987 (/TAS) P13987 (/TAS)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
2 P13987 (/TAS) P13987 (/TAS)
Anchored component of external side of plasma membrane GO:0031362
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
2 P13987 (/IDA) P13987 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P13987 (/HDA) P13987 (/HDA)
Endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
2 P13987 (/TAS) P13987 (/TAS)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 P13987 (/TAS) P13987 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P13987 (/HDA) P13987 (/HDA)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
2 P13987 (/TAS) P13987 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P27274 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P58019 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P58019 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P58019 (/ISO)
Anchored component of external side of plasma membrane GO:0031362
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 P58019 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P27274 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P58019 (/ISO)
Compact myelin GO:0043218
The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.
1 P27274 (/IDA)
Compact myelin GO:0043218
The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.
1 P58019 (/ISO)
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