The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CD59
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 21: Receptor protein serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transforming growth factor beta receptor activity, type I GO:0005025
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
6 Q24326 (/ISS) Q7JQ37 (/ISS) Q7KTP1 (/ISS) Q8IPK9 (/ISS) Q95SI0 (/ISS) Q9VMT1 (/ISS)
Transforming growth factor beta receptor activity, type I GO:0005025
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
6 Q24326 (/NAS) Q7JQ37 (/NAS) Q7KTP1 (/NAS) Q8IPK9 (/NAS) Q95SI0 (/NAS) Q9VMT1 (/NAS)
Transmembrane receptor protein serine/threonine kinase activity GO:0004675
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q9VMT1 (/IDA)
Transmembrane receptor protein serine/threonine kinase activity GO:0004675
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q9VMT1 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q95SI0 (/IPI)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
1 Q9VMT1 (/IPI)
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
1 Q9VMT1 (/IPI)
BMP receptor activity GO:0098821
Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.
1 Q9VMT1 (/IDA)
BMP receptor activity GO:0098821
Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.
1 Q9VMT1 (/IGI)
BMP receptor activity GO:0098821
Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.
1 Q9VMT1 (/IMP)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
6 Q24326 (/NAS) Q7JQ37 (/NAS) Q7KTP1 (/NAS) Q8IPK9 (/NAS) Q95SI0 (/NAS) Q9VMT1 (/NAS)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
6 Q24326 (/TAS) Q7JQ37 (/TAS) Q7KTP1 (/TAS) Q8IPK9 (/TAS) Q95SI0 (/TAS) Q9VMT1 (/TAS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Anterior/posterior pattern specification, imaginal disc GO:0007448
The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Histoblast morphogenesis GO:0007488
The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
6 Q24326 (/TAS) Q7JQ37 (/TAS) Q7KTP1 (/TAS) Q8IPK9 (/TAS) Q95SI0 (/TAS) Q9VMT1 (/TAS)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
6 Q24326 (/TAS) Q7JQ37 (/TAS) Q7KTP1 (/TAS) Q8IPK9 (/TAS) Q95SI0 (/TAS) Q9VMT1 (/TAS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Spectrosome organization GO:0030721
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Genital disc development GO:0035215
Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Germ-line stem cell division GO:0042078
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Regulation of imaginal disc growth GO:0045570
Any process that modulates the frequency, rate or extent of the growth of the imaginal disc.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Negative regulation of salivary gland boundary specification GO:0045705
Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination.
6 Q24326 (/TAS) Q7JQ37 (/TAS) Q7KTP1 (/TAS) Q8IPK9 (/TAS) Q95SI0 (/TAS) Q9VMT1 (/TAS)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Positive regulation of growth GO:0045927
Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Wing disc anterior/posterior pattern formation GO:0048100
The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification GO:0060799
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Anterior Malpighian tubule development GO:0061327
The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Cell elongation involved in imaginal disc-derived wing morphogenesis GO:0090254
The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis.
6 Q24326 (/IMP) Q7JQ37 (/IMP) Q7KTP1 (/IMP) Q8IPK9 (/IMP) Q95SI0 (/IMP) Q9VMT1 (/IMP)
Amnioserosa formation GO:0007378
Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.
1 Q9VMT1 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
1 Q9VMT1 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 Q9VMT1 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 Q9VMT1 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9VMT1 (/IDA)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9VMT1 (/IGI)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9VMT1 (/IMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
1 Q9VMT1 (/IGI)
Wing disc pattern formation GO:0035222
The process giving rise to the pattern of cell differentiation in the wing imaginal disc.
1 Q9VMT1 (/IMP)
R8 cell fate specification GO:0045464
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
1 Q9VMT1 (/IMP)
Dorsal closure, amnioserosa morphology change GO:0046664
The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo.
1 Q9VMT1 (/IMP)
Positive regulation of muscle organ development GO:0048636
Any process that activates, maintains or increases the rate of muscle development.
1 Q9VMT1 (/IMP)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 Q9VMT1 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
6 Q24326 (/IDA) Q7JQ37 (/IDA) Q7KTP1 (/IDA) Q8IPK9 (/IDA) Q95SI0 (/IDA) Q9VMT1 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
6 Q24326 (/IDA) Q7JQ37 (/IDA) Q7KTP1 (/IDA) Q8IPK9 (/IDA) Q95SI0 (/IDA) Q9VMT1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 Q24326 (/HDA) Q7JQ37 (/HDA) Q7KTP1 (/HDA) Q8IPK9 (/HDA) Q95SI0 (/HDA) Q9VMT1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q24326 (/HDA) Q7JQ37 (/HDA) Q7KTP1 (/HDA) Q8IPK9 (/HDA) Q95SI0 (/HDA) Q9VMT1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q24326 (/ISS) Q7JQ37 (/ISS) Q7KTP1 (/ISS) Q8IPK9 (/ISS) Q95SI0 (/ISS) Q9VMT1 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9VMT1 (/IDA)
BMP receptor complex GO:0070724
A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.
1 Q9VMT1 (/IPI)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 Q9VMT1 (/IDA)