The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
GPCR, family 3, nine cysteines domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Taste receptor type 1 member 3-like protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
6 Q7RTX0 (/IDA) Q7RTX1 (/IDA) Q8TE23 (/IDA) Q923K1 (/IDA) Q9Z0R7 (/IDA) Q9Z0R8 (/IDA)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
3 Q925D8 (/ISO) Q925I4 (/ISO) Q99PG6 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 Q7RTX0 (/NAS) Q7RTX1 (/NAS) Q8TE23 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q925D8 (/IPI) Q925I4 (/IPI)
Glutamate binding GO:0016595
Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid.
2 Q5U9X3 (/IDA) Q5U9X3 (/IDA)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
2 Q5U9X3 (/IDA) Q5U9X3 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q8K4Z6 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q925D8 (/TAS)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
5 Q5T6X5 (/TAS) Q7RTX0 (/TAS) Q7RTX1 (/TAS) Q8TE23 (/TAS) Q925D8 (/TAS)
Sensory perception of sweet taste GO:0050916
The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
4 Q7RTX0 (/IDA) Q8TE23 (/IDA) Q923K1 (/IDA) Q9Z0R7 (/IDA)
Sensory perception of umami taste GO:0050917
The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.
4 Q7RTX0 (/IDA) Q7RTX1 (/IDA) Q923K1 (/IDA) Q9Z0R8 (/IDA)
Detection of chemical stimulus involved in sensory perception of sweet taste GO:0001582
The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
2 Q7RTX0 (/IDA) Q8TE23 (/IDA)
Detection of chemical stimulus involved in sensory perception of sweet taste GO:0001582
The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
2 Q925D8 (/ISO) Q925I4 (/ISO)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 Q5U9X3 (/IDA) Q5U9X3 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q7RTX0 (/IC) Q8TE23 (/IC)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
2 Q5T6X5 (/IDA) Q8K4Z6 (/IDA)
Sensory perception of sweet taste GO:0050916
The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
2 Q925D8 (/IGI) Q925I4 (/IGI)
Sensory perception of sweet taste GO:0050916
The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
2 Q925D8 (/ISO) Q925I4 (/ISO)
Sensory perception of umami taste GO:0050917
The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.
2 Q925D8 (/ISO) Q99PG6 (/ISO)
Detection of chemical stimulus involved in sensory perception of sweet taste GO:0001582
The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
1 Q923K1 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q8K4Z6 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q8K4Z6 (/IDA)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q8TE23 (/IMP)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q925I4 (/ISO)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 Q8K4Z6 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 Q7RTX0 (/IC) Q7RTX1 (/IC) Q8TE23 (/IC) Q923K1 (/IC) Q9Z0R7 (/IC) Q9Z0R8 (/IC)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 E1BPQ3 (/ISS) Q5U9X3 (/ISS) Q5U9X3 (/ISS) Q8K4Z6 (/ISS) Q9PW88 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q5T6X5 (/TAS) Q7RTX0 (/TAS) Q7RTX1 (/TAS) Q8TE23 (/TAS)
Sweet taste receptor complex GO:1903767
A protein complex which is capable of sweet taste receptor activity.
2 Q7RTX0 (/IDA) Q8TE23 (/IDA)
Sweet taste receptor complex GO:1903767
A protein complex which is capable of sweet taste receptor activity.
2 Q925D8 (/ISO) Q925I4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q70VB1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8K4Z6 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q925D8 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8K4Z6 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q8TE23 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q925I4 (/ISO)