The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 9: Low-density lipoprotein receptor isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 92 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
44 A2ARV4 (/IPI) A2ARV4 (/IPI) A2ARV4 (/IPI) C0HL13 (/IPI) C0HL13 (/IPI) C0HL13 (/IPI) E1BGJ0 (/IPI) E1BGJ0 (/IPI) E1BGJ0 (/IPI) G3V928 (/IPI)
(34 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
13 A2ARV4 (/ISS) A2ARV4 (/ISS) A2ARV4 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS)
(3 more)
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
10 P01130 (/TAS) P01130 (/TAS) P35951 (/TAS) P35952 (/TAS) P98155 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q14114 (/TAS) Q924X6 (/TAS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
9 A2ARV4 (/ISS) A2ARV4 (/ISS) A2ARV4 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Lipoprotein particle binding GO:0071813
Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
8 A0A0B4KGZ9 (/IPI) A0A0B4KH38 (/IPI) A8JRC4 (/IPI) A8JRC7 (/IPI) Q7YTZ6 (/IPI) Q7YU01 (/IPI) Q86B77 (/IPI) Q9VBN2 (/IPI)
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
7 P01130 (/IDA) P01130 (/IDA) P35951 (/IDA) P35952 (/IDA) Q9JI18 (/IDA) Q9JI18 (/IDA) Q9JI18 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
7 P98158 (/TAS) P98158 (/TAS) P98158 (/TAS) P98158 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
7 A8JRD0 (/IMP) Q07954 (/IMP) Q07954 (/IMP) Q07954 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
6 P98164 (/IDA) P98164 (/IDA) P98164 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
6 P98165 (/IPI) P98165 (/IPI) Q07954 (/IPI) Q07954 (/IPI) Q07954 (/IPI) Q9QYP1 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
6 C0HL13 (/IPI) C0HL13 (/IPI) C0HL13 (/IPI) P98164 (/IPI) P98164 (/IPI) P98164 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
5 G3V928 (/IPI) G3V928 (/IPI) G3V928 (/IPI) P01130 (/IPI) P01130 (/IPI)
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
5 E9QGD4 (/IMP) P01130 (/IMP) P01130 (/IMP) P35951 (/IMP) Q7ZZT0 (/IMP)
Alpha-2 macroglobulin receptor activity GO:0016964
Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.
5 P98157 (/ISS) P98157 (/ISS) Q91ZX7 (/ISS) Q91ZX7 (/ISS) Q91ZX7 (/ISS)
Very-low-density lipoprotein particle receptor activity GO:0030229
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
5 P01130 (/IDA) P01130 (/IDA) P35951 (/IDA) P98155 (/IDA) Q14114 (/IDA)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
5 P98155 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q924X6 (/IDA)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
5 P98156 (/ISO) Q8VI56 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
4 P35951 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
4 P98158 (/IPI) P98158 (/IPI) P98158 (/IPI) P98158 (/IPI)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Steroid hormone receptor binding GO:0035258
Interacting selectively and non-covalently with a steroid hormone receptor.
4 P98158 (/IPI) P98158 (/IPI) P98158 (/IPI) P98158 (/IPI)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
4 P98156 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
4 Q07954 (/NAS) Q07954 (/NAS) Q07954 (/NAS) Q14114 (/NAS)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
4 P98158 (/IPI) P98158 (/IPI) P98158 (/IPI) P98158 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 P98158 (/IPI) P98158 (/IPI) P98158 (/IPI) P98158 (/IPI)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
4 P98158 (/IPI) P98158 (/IPI) P98158 (/IPI) P98158 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
3 Q07954 (/IC) Q07954 (/IC) Q07954 (/IC)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 Q07954 (/HDA) Q07954 (/HDA) Q07954 (/HDA)
Scavenger receptor activity GO:0005044
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Alpha-2 macroglobulin receptor activity GO:0016964
Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.
3 Q07954 (/IMP) Q07954 (/IMP) Q07954 (/IMP)
Alpha-2 macroglobulin receptor activity GO:0016964
Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Alpha-2 macroglobulin receptor activity GO:0016964
Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Apolipoprotein receptor activity GO:0030226
Combining with an apolipoprotein to initiate a change in cell activity.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Very-low-density lipoprotein particle receptor activity GO:0030229
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
3 P35951 (/ISO) P98156 (/ISO) Q924X6 (/ISO)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
3 Q07954 (/IPI) Q07954 (/IPI) Q07954 (/IPI)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Steroid hormone receptor binding GO:0035258
Interacting selectively and non-covalently with a steroid hormone receptor.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
3 Q07954 (/IDA) Q07954 (/IDA) Q07954 (/IDA)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
3 Q9JI18 (/IDA) Q9JI18 (/IDA) Q9JI18 (/IDA)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
3 P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Lipoprotein particle receptor binding GO:0070325
Interacting selectively and non-covalently with a lipoprotein particle receptor.
3 Q07954 (/IC) Q07954 (/IC) Q07954 (/IC)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
2 P35951 (/IPI) Q924X6 (/IPI)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
2 P01130 (/ISS) P01130 (/ISS)
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
2 P01130 (/IC) P01130 (/IC)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
2 P01130 (/IMP) P01130 (/IMP)
Lipoprotein particle receptor activity GO:0030228
Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
2 P98165 (/IC) P98165 (/IC)
Very-low-density lipoprotein particle receptor activity GO:0030229
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
2 P98156 (/ISS) P98166 (/ISS)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
2 Q8VI56 (/IPI) Q9QYP1 (/IPI)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
2 P01130 (/TAS) P01130 (/TAS)
Reelin receptor activity GO:0038025
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P98156 (/IMP) Q924X6 (/IMP)
Reelin receptor activity GO:0038025
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P98155 (/ISS) Q14114 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P01130 (/IPI) P01130 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
2 P98155 (/IPI) Q924X6 (/IPI)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 Q14114 (/TAS)
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
1 P35951 (/ISO)
High-density lipoprotein particle binding GO:0008035
Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.
1 D3ZE75 (/IDA)
High-density lipoprotein particle binding GO:0008035
Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.
1 Q924X6 (/ISO)
Vitellogenin receptor activity GO:0008196
Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.
1 P98163 (/ISS)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 D3ZE75 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q924X6 (/ISO)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
1 P35951 (/IDA)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
1 P35951 (/ISO)
Very-low-density lipoprotein particle receptor activity GO:0030229
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
1 P98155 (/TAS)
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
1 P98166 (/TAS)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q8VI56 (/ISO)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
1 Q14114 (/IC)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
1 P98155 (/ISS)
Very-low-density lipoprotein particle binding GO:0034189
Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.
1 P98155 (/IDA)
Very-low-density lipoprotein particle binding GO:0034189
Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.
1 P98156 (/ISO)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
1 P98155 (/IDA)
Reelin receptor activity GO:0038025
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P98156 (/IGI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P35951 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8VI56 (/IDA)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q924X6 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P98156 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 Q9QYP1 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 Q8VI56 (/ISO)

There are 357 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
29 A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
(19 more)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
15 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P35951 (/IDA) P98155 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98164 (/IDA)
(5 more)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
14 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P01130 (/ISS) P01130 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
(4 more)
Renal absorption GO:0070293
A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
12 A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IAG0 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) A0A0R4IVD8 (/IMP) E0AE56 (/IMP) E0AE56 (/IMP)
(2 more)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
11 P01130 (/TAS) P01130 (/TAS) P98164 (/TAS) P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q9NZR2 (/TAS) Q9NZR2 (/TAS)
(1 more)
Positive regulation of lipid transport GO:0032370
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
11 A0A0B4KGZ9 (/IMP) A0A0B4KH38 (/IMP) A8JRC4 (/IMP) A8JRC7 (/IMP) Q7YTZ6 (/IMP) Q7YU01 (/IMP) Q86B77 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
(1 more)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Secondary heart field specification GO:0003139
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Ventricular compact myocardium morphogenesis GO:0003223
The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Vagina development GO:0060068
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Coronary artery morphogenesis GO:0060982
The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Pulmonary artery morphogenesis GO:0061156
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Positive regulation of oligodendrocyte progenitor proliferation GO:0070447
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Neuron projection arborization GO:0140058
The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Folate import across plasma membrane GO:1904447
The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
9 P01130 (/TAS) P01130 (/TAS) P98164 (/TAS) P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q14114 (/TAS)
Regulation of vasculature development GO:1901342
Any process that modulates the frequency, rate or extent of vasculature development.
9 A0A0H2UKL4 (/IMP) A0A0H2UKL4 (/IMP) A0A0H2UKL4 (/IMP) A0A140LH43 (/IMP) A0A140LH43 (/IMP) F1QY34 (/IMP) F1QY34 (/IMP) F1QY34 (/IMP) X1WHG6 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
8 G3V928 (/IEP) G3V928 (/IEP) G3V928 (/IEP) P35952 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
7 P98164 (/TAS) P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q14114 (/TAS)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
7 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) P98156 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Metal ion transport GO:0030001
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
7 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98164 (/IDA) P98164 (/IDA) P98164 (/IDA)
Chemoattraction of axon GO:0061642
The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
7 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
7 O75096 (/IMP) Q07954 (/IMP) Q07954 (/IMP) Q07954 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
6 C0HL13 (/IGI) C0HL13 (/IGI) C0HL13 (/IGI) Q91ZX7 (/IGI) Q91ZX7 (/IGI) Q91ZX7 (/IGI)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
6 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP) G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Metal ion transport GO:0030001
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 A2ARV4 (/ISS) A2ARV4 (/ISS) A2ARV4 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
6 D3ZE75 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98166 (/IEP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
6 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Chemoattraction of axon GO:0061642
The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
5 P35952 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
5 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) P35951 (/ISO) Q924X6 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
5 P01130 (/TAS) P01130 (/TAS) P98164 (/TAS) P98164 (/TAS) P98164 (/TAS)
Ventral spinal cord development GO:0021517
The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.
5 P98156 (/IEP) P98165 (/IEP) P98165 (/IEP) Q924X6 (/IEP) Q98931 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
5 D3ZE75 (/IEP) G3V928 (/IEP) G3V928 (/IEP) G3V928 (/IEP) P98166 (/IEP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
5 E9QGD4 (/IMP) P01130 (/IMP) P01130 (/IMP) P35951 (/IMP) Q7ZZT0 (/IMP)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
5 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) Q28832 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
5 P01130 (/TAS) P01130 (/TAS) P98164 (/TAS) P98164 (/TAS) P98164 (/TAS)
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
5 P01130 (/ISS) P01130 (/ISS) Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Positive regulation of lysosomal protein catabolic process GO:1905167
Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.
5 P01130 (/ISS) P01130 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Vitamin metabolic process GO:0006766
The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
4 P98158 (/TAS) P98158 (/TAS) P98158 (/TAS) P98158 (/TAS)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
4 P35951 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Response to X-ray GO:0010165
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
4 P98158 (/IC) P98158 (/IC) P98158 (/IC) P98158 (/IC)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
4 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Endocytic hemoglobin import GO:0020028
The directed movement into a tissue or a cell or organelle of externally available hemoglobin by receptor-mediated endocytosis.
4 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
4 A8JTM7 (/IMP) A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
4 P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
4 P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP)
Response to vitamin D GO:0033280
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
4 P98158 (/IEP) P98158 (/IEP) P98158 (/IEP) P98158 (/IEP)
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
4 A8JTM7 (/IMP) A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
4 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Hormone secretion GO:0046879
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
4 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
4 A8JTM7 (/IMP) A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Skeletal muscle acetylcholine-gated channel clustering GO:0071340
The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Receptor-mediated endocytosis involved in cholesterol transport GO:0090118
A receptor-mediated endocytosis process involved in intracellular cholesterol transport.
4 E9QGD4 (/IMP) P01130 (/IMP) P01130 (/IMP) Q7ZZT0 (/IMP)
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Presynaptic membrane assembly GO:0097105
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Positive regulation of lipoprotein transport GO:0140077
Any process that activates or increases the rate or extent of lipoprotein transport.
4 P98158 (/IMP) P98158 (/IMP) P98158 (/IMP) P98158 (/IMP)
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
4 P35951 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA)
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
4 Q8VI56 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of presynaptic membrane organization GO:1901631
Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Positive regulation of lysosomal protein catabolic process GO:1905167
Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.
4 C0HL13 (/IDA) C0HL13 (/IDA) C0HL13 (/IDA) P35951 (/IDA)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
3 Q9JI18 (/IMP) Q9JI18 (/IMP) Q9JI18 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Astrocyte activation involved in immune response GO:0002265
A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
3 Q91ZX7 (/IGI) Q91ZX7 (/IGI) Q91ZX7 (/IGI)
Astrocyte activation involved in immune response GO:0002265
A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Secondary heart field specification GO:0003139
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Ventricular compact myocardium morphogenesis GO:0003223
The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Cardiac septum development GO:0003279
The progression of a cardiac septum over time, from its initial formation to the mature structure.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Vitamin metabolic process GO:0006766
The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Vitamin metabolic process GO:0006766
The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
3 Q7Z5C0 (/ISS) Q7Z5C0 (/ISS) Q7Z5C0 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
3 Q07954 (/IMP) Q07954 (/IMP) Q07954 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
3 Q07954 (/NAS) Q07954 (/NAS) Q07954 (/NAS)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
3 Q91ZX7 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
3 P01130 (/IGI) P01130 (/IGI) P35951 (/IGI)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Response to X-ray GO:0010165
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Regulation of extracellular matrix disassembly GO:0010715
Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
3 Q07954 (/IGI) Q07954 (/IGI) Q07954 (/IGI)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q9NZR2 (/TAS) Q9NZR2 (/TAS) Q9NZR2 (/TAS)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Endocytic hemoglobin import GO:0020028
The directed movement into a tissue or a cell or organelle of externally available hemoglobin by receptor-mediated endocytosis.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Metal ion transport GO:0030001
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
3 Q91ZX7 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P01130 (/IMP) P01130 (/IMP) P35951 (/IMP)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
3 Q07954 (/IGI) Q07954 (/IGI) Q07954 (/IGI)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of lipid transport GO:0032370
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Regulation of cholesterol transport GO:0032374
Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Regulation of cholesterol transport GO:0032374
Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Regulation of phospholipase A2 activity GO:0032429
Any process that modulates the activity of the enzyme phospholipase A2.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Regulation of phospholipase A2 activity GO:0032429
Any process that modulates the activity of the enzyme phospholipase A2.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
3 P01130 (/IMP) P01130 (/IMP) P35951 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Aorta development GO:0035904
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Aorta morphogenesis GO:0035909
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Aorta morphogenesis GO:0035909
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
3 G3V928 (/IEP) G3V928 (/IEP) G3V928 (/IEP)
Vitamin D metabolic process GO:0042359
The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
3 P98164 (/TAS) P98164 (/TAS) P98164 (/TAS)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
3 P01130 (/IGI) P01130 (/IGI) P35951 (/IGI)
Lipoprotein transport GO:0042953
The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q07954 (/NAS) Q07954 (/NAS) Q07954 (/NAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Cellular lipid catabolic process GO:0044242
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Cellular lipid catabolic process GO:0044242
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
3 Q07954 (/IGI) Q07954 (/IGI) Q07954 (/IGI)
Hormone secretion GO:0046879
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of collateral sprouting of injured axon GO:0048694
Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Positive regulation of collateral sprouting of injured axon GO:0048694
Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
3 P98156 (/IMP) Q924X6 (/IMP) Q9QYP1 (/IMP)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
3 P01130 (/IGI) P01130 (/IGI) P35951 (/IGI)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Vagina development GO:0060068
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Coronary artery morphogenesis GO:0060982
The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Pulmonary artery morphogenesis GO:0061156
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Response to caloric restriction GO:0061771
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake.
3 P01130 (/IGI) P01130 (/IGI) P35951 (/IGI)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of oligodendrocyte progenitor proliferation GO:0070447
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Cholesterol import GO:0070508
The directed movement of cholesterol into a cell or organelle.
3 P01130 (/IMP) P01130 (/IMP) P35951 (/IMP)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
3 Q07954 (/NAS) Q07954 (/NAS) Q07954 (/NAS)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Neuron projection arborization GO:0140058
The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Positive regulation of lipoprotein transport GO:0140077
Any process that activates or increases the rate or extent of lipoprotein transport.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Amyloid-beta clearance by transcytosis GO:0150093
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
3 Q07954 (/IGI) Q07954 (/IGI) Q07954 (/IGI)
Amyloid-beta clearance by transcytosis GO:0150093
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
3 Q91ZX7 (/IGI) Q91ZX7 (/IGI) Q91ZX7 (/IGI)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
3 Q07954 (/IGI) Q07954 (/IGI) Q07954 (/IGI)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of cholesterol import GO:1904109
Any process that activates or increases the frequency, rate or extent of cholesterol import.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of cholesterol import GO:1904109
Any process that activates or increases the frequency, rate or extent of cholesterol import.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of chemokine (C-C motif) ligand 2 secretion GO:1904209
Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of chemokine (C-C motif) ligand 2 secretion GO:1904209
Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Folate import across plasma membrane GO:1904447
The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol.
3 A2ARV4 (/IMP) A2ARV4 (/IMP) A2ARV4 (/IMP)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
3 Q91ZX7 (/IGI) Q91ZX7 (/IGI) Q91ZX7 (/IGI)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Positive regulation of vascular associated smooth muscle cell migration GO:1904754
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.
3 G3V928 (/IMP) G3V928 (/IMP) G3V928 (/IMP)
Positive regulation of vascular associated smooth muscle cell migration GO:1904754
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Positive regulation of lysosomal protein catabolic process GO:1905167
Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.
3 Q07954 (/IMP) Q07954 (/IMP) Q07954 (/IMP)
Positive regulation of lysosomal protein catabolic process GO:1905167
Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
3 Q91ZX7 (/IMP) Q91ZX7 (/IMP) Q91ZX7 (/IMP)
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P35952 (/IEP) P98166 (/IEP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P01130 (/ISS) P01130 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P98155 (/TAS) Q14114 (/TAS)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 P35952 (/IEP) P98166 (/IEP)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
2 P01130 (/ISS) P01130 (/ISS)
Regulation of phosphatidylcholine catabolic process GO:0010899
Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
2 P01130 (/ISS) P01130 (/ISS)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
2 P01130 (/ISS) P01130 (/ISS)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
2 P01130 (/IMP) P01130 (/IMP)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P01130 (/TAS) P01130 (/TAS)
Plasma lipoprotein particle clearance GO:0034381
The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
2 P01130 (/ISS) P01130 (/ISS)
Plasma lipoprotein particle clearance GO:0034381
The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
2 P01130 (/TAS) P01130 (/TAS)
Chylomicron remnant clearance GO:0034382
The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.
2 P01130 (/TAS) P01130 (/TAS)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
2 P01130 (/TAS) P01130 (/TAS)
Very-low-density lipoprotein particle clearance GO:0034447
The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
2 P98156 (/ISS) P98166 (/ISS)
Reelin-mediated signaling pathway GO:0038026
A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P98155 (/ISS) Q14114 (/ISS)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
2 P01130 (/TAS) P01130 (/TAS)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 P98156 (/IGI) Q924X6 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q8VI56 (/IMP) Q924X6 (/IMP)
Negative regulation of protein metabolic process GO:0051248
Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
2 P01130 (/ISS) P01130 (/ISS)
Negative regulation of astrocyte activation GO:0061889
Any process that decreases the frequency, rate or extent of astrocyte activation.
2 P01130 (/ISS) P01130 (/ISS)
Cholesterol import GO:0070508
The directed movement of cholesterol into a cell or organelle.
2 P01130 (/ISS) P01130 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 E9QGD4 (/IMP) Q7ZZT0 (/IMP)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
2 P01130 (/IMP) P01130 (/IMP)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 O75096 (/IDA) Q8VI56 (/IDA)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
2 P01130 (/ISS) P01130 (/ISS)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
2 P98156 (/IGI) Q924X6 (/IGI)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
2 P98155 (/ISS) Q14114 (/ISS)
Negative regulation of microglial cell activation GO:1903979
Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation.
2 P01130 (/ISS) P01130 (/ISS)
Negative regulation of amyloid fibril formation GO:1905907
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
2 P01130 (/ISS) P01130 (/ISS)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 O75096 (/IDA)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q8VI56 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q8VI56 (/ISO)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 Q8VI56 (/IMP)
Hair follicle development GO:0001942
The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
1 Q8VI56 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q14114 (/NAS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 P35951 (/IGI)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q14114 (/NAS)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q14114 (/IDA)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q924X6 (/ISS)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 A8JRD0 (/IEP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P35951 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P98166 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q924X6 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P98155 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P98155 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P98166 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P98166 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P98155 (/TAS)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 P35951 (/ISO)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
1 Q8VI56 (/IMP)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 Q8VI56 (/IMP)
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
1 Q8VI56 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P35951 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P35951 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P35951 (/IMP)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
1 P35951 (/IMP)
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
1 P35952 (/IMP)
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
1 P35951 (/ISO)
Regulation of phosphatidylcholine catabolic process GO:0010899
Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 P35951 (/IMP)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
1 P35951 (/IMP)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 Q8VI56 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q14114 (/NAS)
Ammon gyrus development GO:0021541
The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.
1 Q924X6 (/IMP)
Ammon gyrus development GO:0021541
The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.
1 Q14114 (/ISS)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q924X6 (/IGI)
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
1 Q924X6 (/IGI)
Negative regulation of ossification GO:0030279
Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 O75096 (/IMP)
Negative regulation of ossification GO:0030279
Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 Q8VI56 (/ISO)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
1 P35951 (/ISO)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P35951 (/ISO)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
1 Q8VI56 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P35952 (/IEP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P98166 (/IEP)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 Q924X6 (/IMP)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 Q14114 (/ISS)
Low-density lipoprotein particle receptor catabolic process GO:0032802
The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P98155 (/TAS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P98166 (/IEP)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
1 P35952 (/IEP)
Plasma lipoprotein particle clearance GO:0034381
The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P35951 (/IDA)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P35951 (/IDA)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P35951 (/ISO)
High-density lipoprotein particle clearance GO:0034384
The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P35951 (/IGI)
Glycoprotein transport GO:0034436
The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P98155 (/IDA)
Glycoprotein transport GO:0034436
The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P98156 (/ISO)
Very-low-density lipoprotein particle clearance GO:0034447
The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P98155 (/IDA)
Very-low-density lipoprotein particle clearance GO:0034447
The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P98156 (/ISO)
Very-low-density lipoprotein particle clearance GO:0034447
The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 P98155 (/TAS)
Reelin-mediated signaling pathway GO:0038026
A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P98156 (/IGI)
Reelin-mediated signaling pathway GO:0038026
A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q924X6 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
1 P98166 (/IEP)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P35951 (/IGI)
Lipoprotein catabolic process GO:0042159
The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P35951 (/IDA)
Lipoprotein catabolic process GO:0042159
The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P35951 (/IMP)
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
1 Q8VI56 (/IMP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 P35951 (/ISO)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
1 Q8VI56 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q924X6 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q14114 (/ISS)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 Q8VI56 (/IMP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 P35952 (/IEP)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q924X6 (/IMP)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q14114 (/ISS)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 P98163 (/TAS)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q8VI56 (/ISO)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
1 P35951 (/IMP)
Anatomical structure development GO:0048856
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
1 Q8VI56 (/IMP)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 P35951 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 Q14114 (/ISS)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
1 Q8VI56 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 Q924X6 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 Q14114 (/ISS)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q9QYP1 (/IMP)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q8VI56 (/ISO)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
1 Q8VI56 (/IDA)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
1 Q8VI56 (/IMP)
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
1 P35951 (/ISO)
Negative regulation of protein metabolic process GO:0051248
Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
1 P35951 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
1 Q9QYP1 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
1 Q8VI56 (/ISO)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
1 O75096 (/IDA)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
1 Q8VI56 (/ISO)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q924X6 (/IMP)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q14114 (/ISS)
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
1 Q924X6 (/IMP)
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
1 Q14114 (/ISS)
Response to caloric restriction GO:0061771
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake.
1 P35951 (/ISO)
Negative regulation of astrocyte activation GO:0061889
Any process that decreases the frequency, rate or extent of astrocyte activation.
1 P35951 (/IGI)
Cholesterol import GO:0070508
The directed movement of cholesterol into a cell or organelle.
1 P35951 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P98166 (/IEP)
Skeletal muscle acetylcholine-gated channel clustering GO:0071340
The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
1 Q8VI56 (/IMP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P98166 (/IEP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 D3ZE75 (/IEP)
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
1 D3ZE75 (/IEP)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 P35951 (/IGI)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
1 P35951 (/ISO)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P98166 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P98156 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q8VI56 (/IGI)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 O75096 (/IMP)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q8VI56 (/ISO)
Receptor-mediated endocytosis involved in cholesterol transport GO:0090118
A receptor-mediated endocytosis process involved in intracellular cholesterol transport.
1 P35951 (/ISO)
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P35951 (/IGI)
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
1 Q8VI56 (/IMP)
Presynaptic membrane assembly GO:0097105
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
1 Q8VI56 (/IMP)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 P35951 (/IGI)
Positive regulation of presynaptic membrane organization GO:1901631
Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization.
1 Q8VI56 (/IDA)
Negative regulation of microglial cell activation GO:1903979
Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation.
1 P35951 (/IGI)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904395
Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
1 Q8VI56 (/IMP)
Negative regulation of amyloid fibril formation GO:1905907
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
1 P35951 (/IGI)
Presynaptic active zone organization GO:1990709
A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone.
1 Q9VXM0 (/IMP)

There are 126 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
18 P98164 (/HDA) P98164 (/HDA) P98164 (/HDA) Q07954 (/HDA) Q07954 (/HDA) Q07954 (/HDA) Q4ZG84 (/HDA) Q4ZG84 (/HDA) Q4ZG84 (/HDA) Q59FG2 (/HDA)
(8 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
16 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) D3ZE75 (/IDA) P98155 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) Q90W12 (/IDA)
(6 more)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
14 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) A8JTM7 (/IDA) A8JTM7 (/IDA) A8JTM7 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
(4 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
14 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS)
(4 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 A0A0B4KGZ9 (/IDA) A0A0B4KH38 (/IDA) A8JRC4 (/IDA) A8JRC7 (/IDA) E1BGJ0 (/IDA) E1BGJ0 (/IDA) E1BGJ0 (/IDA) P35952 (/IDA) Q7YTZ6 (/IDA) Q7YU01 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 P01130 (/TAS) P01130 (/TAS) P35951 (/TAS) P98155 (/TAS) P98164 (/TAS) P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
(3 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
13 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) P01130 (/ISS) P01130 (/ISS) P01131 (/ISS) P20063 (/ISS) P35950 (/ISS) P35951 (/ISS) P35952 (/ISS)
(3 more)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
13 P01130 (/IDA) P01130 (/IDA) P98155 (/IDA) P98164 (/IDA) P98164 (/IDA) P98164 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q14114 (/IDA)
(3 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
12 O75096 (/IDA) P01130 (/IDA) P01130 (/IDA) P01131 (/IDA) P35951 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98166 (/IDA)
(2 more)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
12 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) P35951 (/ISO) P98156 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q924X6 (/ISO) Q9JI18 (/ISO)
(2 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
11 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA) P35951 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
(1 more)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
10 C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98158 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
9 A2ARV4 (/ISS) A2ARV4 (/ISS) A2ARV4 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
9 A2ARV4 (/ISS) A2ARV4 (/ISS) A2ARV4 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) P98164 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 A0A0B4KFD1 (/HDA) A0A0B4KFD1 (/HDA) A1Z7C4 (/HDA) A1Z7C4 (/HDA) A8JTM7 (/HDA) A8JTM7 (/HDA) A8JTM7 (/HDA) Q95SN5 (/HDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
8 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) D3ZE75 (/IDA) G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA) Q9QYP1 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
8 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA) P35951 (/IDA) P98166 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
7 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
7 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
7 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P98156 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) Q924X6 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
6 P01131 (/ISS) P20063 (/ISS) P35950 (/ISS) P35951 (/ISS) P35952 (/ISS) Q28832 (/ISS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
6 P01130 (/IDA) P01130 (/IDA) P35951 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q07954 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
6 P01131 (/ISS) P20063 (/ISS) P35950 (/ISS) P35951 (/ISS) P35952 (/ISS) Q28832 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
6 P01131 (/ISS) P20063 (/ISS) P35950 (/ISS) P35951 (/ISS) P35952 (/ISS) Q28832 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
6 P01131 (/ISS) P20063 (/ISS) P35950 (/ISS) P35951 (/ISS) P35952 (/ISS) Q28832 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) P35951 (/ISO) P98156 (/ISO) Q8VI56 (/ISO)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
6 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
5 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P01130 (/IDA) P01130 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
5 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P01130 (/IDA) P01130 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
5 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) P01130 (/IDA) P01130 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO) P98156 (/ISO) Q924X6 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
5 Q8VI56 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q924X6 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
5 D3ZE75 (/IDA) G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA) Q9QYP1 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
5 Q8VI56 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q924X6 (/ISO)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
5 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS) Q9VXM0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 P35951 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A8JTM7 (/HDA) A8JTM7 (/HDA) A8JTM7 (/HDA) Q95SN5 (/HDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 P35951 (/IDA) Q07954 (/IDA) Q07954 (/IDA) Q07954 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
4 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA) D3ZE75 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q9QYP1 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
4 H2Q3I3 (/ISS) H9FUD8 (/ISS) O75096 (/ISS) Q8VI56 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P98158 (/IDA) P98158 (/IDA) P98158 (/IDA) P98158 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
4 P98156 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P98156 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 P01130 (/IDA) P01130 (/IDA) P35951 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 P98164 (/TAS) P98164 (/TAS) P98164 (/TAS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
3 Q7Z5C0 (/ISS) Q7Z5C0 (/ISS) Q7Z5C0 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
3 P01130 (/IDA) P01130 (/IDA) P35951 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q91ZX7 (/IDA) Q91ZX7 (/IDA) Q91ZX7 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q07954 (/ISS) Q07954 (/ISS) Q07954 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
3 P01131 (/IDA) P35952 (/IDA) Q14114 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
3 Q7Z5C0 (/ISS) Q7Z5C0 (/ISS) Q7Z5C0 (/ISS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 Q07954 (/HDA) Q07954 (/HDA) Q07954 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P01130 (/HDA) P01130 (/HDA) Q14114 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q07954 (/NAS) Q07954 (/NAS) Q07954 (/NAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
3 A2ARV4 (/IDA) A2ARV4 (/IDA) A2ARV4 (/IDA)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
3 P98164 (/TAS) P98164 (/TAS) P98164 (/TAS)
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Insulin-responsive compartment GO:0032593
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
3 G3V928 (/IDA) G3V928 (/IDA) G3V928 (/IDA)
Insulin-responsive compartment GO:0032593
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
3 Q91ZX7 (/ISO) Q91ZX7 (/ISO) Q91ZX7 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 A2ARV4 (/ISO) A2ARV4 (/ISO) A2ARV4 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P98164 (/HDA) P98164 (/HDA) P98164 (/HDA)
Plasma membrane protein complex GO:0098797
Any protein complex that is part of the plasma membrane.
3 Q07954 (/TAS) Q07954 (/TAS) Q07954 (/TAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 P01130 (/ISS) P01130 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P01130 (/TAS) P01130 (/TAS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 P35951 (/ISO) Q924X6 (/ISO)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
2 P01130 (/TAS) P01130 (/TAS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 D3ZE75 (/IDA) Q9QYP1 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 Q8VI56 (/ISO) Q924X6 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P01130 (/ISS) P01130 (/ISS)
Clathrin-coated endocytic vesicle membrane GO:0030669
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
2 P01130 (/TAS) P01130 (/TAS)
Endolysosome membrane GO:0036020
The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
2 P01130 (/TAS) P01130 (/TAS)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 P01130 (/ISS) P01130 (/ISS)
PCSK9-LDLR complex GO:1990666
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
2 P01130 (/IDA) P01130 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P35951 (/HDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 P35951 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P98166 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P98156 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P35951 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 P98155 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 P35951 (/ISO)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 P01131 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 P35951 (/ISO)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 D3ZE75 (/IDA)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 Q924X6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P35951 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O75096 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q14114 (/NAS)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 P35951 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P35951 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q14114 (/IC)
Coated vesicle GO:0030135
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
1 P98163 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q924X6 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 P98163 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 Q8VI56 (/IC)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 Q8VI56 (/IDA)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
1 P35951 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 Q9VXM0 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 H0Z4W1 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 Q9QYP1 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 Q8VI56 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P98166 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
1 P35952 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
1 P35951 (/ISO)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 Q9QYP1 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 Q8VI56 (/ISO)
Sorting endosome GO:0097443
A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.
1 P35951 (/IDA)
PCSK9-LDLR complex GO:1990666
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
1 P35951 (/ISO)
PCSK9-LDLR complex GO:1990666
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
1 P35951 (/ISS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...