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CATH Superfamily 2.10.25.10

Laminin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 162: Coagulation factor X (Predicted)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Coagulation factor Xa. [EC: 3.4.21.6]
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
 36 A0A2R9B696 A0A2R9B696 A0A2R9B696 A0A2R9B696 A6MFK7 A6MFK8 B5G6G5 H2Q7T9 H2Q7T9 H2Q7T9
(26 more...)
Coagulation factor IXa. [EC: 3.4.21.22]
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
  • The proenzyme factor IX is activated by EC 3.4.21.27.
  • Belongs to peptidase family S1.
 12 A0A2J8IT47 A0A2J8IT47 P00740 P00741 P16293 P16294 P16296 P19540 Q6SA95 Q804X6
(2 more...)
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