The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Heat shock protein DnaJ, cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Molecular chaperone DnaJ

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P08622 (/IPI) P08622 (/IPI) P08622 (/IPI) P08622 (/IPI) P08622 (/IPI) P95830 (/IPI) P95830 (/IPI) P95830 (/IPI) P95830 (/IPI) P95830 (/IPI)
(3 more)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
5 P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP)
Protein disulfide oxidoreductase activity GO:0015035
Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Sigma factor antagonist activity GO:0016989
The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
5 P08622 (/IPI) P08622 (/IPI) P08622 (/IPI) P08622 (/IPI) P08622 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
12 P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA)
(2 more)
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
12 P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA) P9WNV9 (/IDA)
(2 more)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
10 O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) O34242 (/ISS) Q2GI75 (/ISS) Q607A6 (/ISS)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
5 P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
5 P08622 (/IEP) P08622 (/IEP) P08622 (/IEP) P08622 (/IEP) P08622 (/IEP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
5 P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
5 Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS) Q9U0J2 (/TAS)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
5 P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP) P08622 (/IMP)
Protein refolding GO:0042026
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Chaperone cofactor-dependent protein refolding GO:0051085
The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Nuclear membrane fusion GO:0000740
The joining of 2 or more lipid bilayer membranes that surround the nucleus.
2 Q8GWW8 (/IMP) Q8GWW8 (/IMP)
Embryo sac development GO:0009553
The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
2 Q8GWW8 (/IMP) Q8GWW8 (/IMP)
Embryo sac cellularization GO:0009558
The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana.
2 Q8GWW8 (/IMP) Q8GWW8 (/IMP)
Polar nucleus fusion GO:0010197
The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized.
2 Q8GWW8 (/IMP) Q8GWW8 (/IMP)
Synergid death GO:0010198
Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles.
2 Q8GWW8 (/IMP) Q8GWW8 (/IMP)
Chaperone cofactor-dependent protein refolding GO:0051085
The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
2 Q8GWW8 (/IGI) Q8GWW8 (/IGI)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
12 P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA) P9WNV9 (/HDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Apicoplast GO:0020011
The plastid organelle found in apicomplexans.
5 Q9U0J2 (/RCA) Q9U0J2 (/RCA) Q9U0J2 (/RCA) Q9U0J2 (/RCA) Q9U0J2 (/RCA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA) P08622 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 Q058J9 (/IDA) Q0WN54 (/IDA) Q940V1 (/IDA) Q9SJZ7 (/IDA)
Chloroplast thylakoid membrane GO:0009535
The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
3 Q0WN54 (/IDA) Q940V1 (/IDA) Q9SJZ7 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
3 Q0WN54 (/IDA) Q940V1 (/IDA) Q9SJZ7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8GWW8 (/IDA) Q8GWW8 (/IDA)
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