CATH Superfamily 2.10.220.10
Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
".
FunFam 9: Receptor protein-tyrosine kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 28 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
RNA polymerase I core binding GO:0001042
Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P04626 (/IPI) P04626 (/IPI) P06494 (/IPI) P70424 (/IPI) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
3 | P04626 (/IDA) P04626 (/IDA) P06494 (/IDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | P04626 (/IPI) P04626 (/IPI) P06494 (/IPI) |
RNA polymerase I core binding GO:0001042
Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
|
2 | P04626 (/IDA) P04626 (/IDA) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | P04626 (/IGI) P04626 (/IGI) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | P04626 (/TAS) P04626 (/TAS) |
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
2 | P04626 (/IDA) P04626 (/IDA) |
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
2 | P04626 (/IDA) P04626 (/IDA) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
2 | P04626 (/IPI) P04626 (/IPI) |
Showing 1 to 10 of 28 entries
There are 110 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Regulation of microtubule-based process GO:0032886
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
|
5 | O18735 (/ISS) P06494 (/ISS) P70424 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | P04626 (/IDA) P04626 (/IDA) P06494 (/IDA) |
Showing 1 to 10 of 110 entries
There are 35 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | B4DTR1 (/IDA) F5H1T4 (/IDA) J3QLU9 (/IDA) P04626 (/IDA) P04626 (/IDA) P70424 (/IDA) X5DNK3 (/IDA) X5DNK3 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | B4DTR1 (/IDA) P04626 (/IDA) P04626 (/IDA) X5DNK3 (/IDA) X5DNK3 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P04626 (/IDA) P04626 (/IDA) P06494 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | O18735 (/ISS) Q60553 (/ISS) Q60553 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P04626 (/TAS) P04626 (/TAS) P06494 (/TAS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P04626 (/NAS) P04626 (/NAS) P70424 (/NAS) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
3 | P04626 (/IDA) P04626 (/IDA) P06494 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P04626 (/NAS) P04626 (/NAS) |
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
2 | P04626 (/IDA) P04626 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | P06494 (/IDA) P70424 (/IDA) |
Showing 1 to 10 of 35 entries