CATH Superfamily 2.10.220.10
Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
".
FunFam 3: R-spondin 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
5 | Q2MKA7 (/IPI) Q2TJ95 (/IPI) Q9BXY4 (/IPI) Q9BXY4 (/IPI) Q9Z132 (/IPI) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | Q2TJ95 (/ISO) Q9Z132 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q2MKA7 (/IPI) Q9Z132 (/IPI) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
2 | Q2TJ95 (/IDA) Q9Z132 (/IDA) |
|
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
1 | Q2MKA7 (/IPI) |
|
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
1 | Q9Z132 (/ISO) |
|
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
|
1 | Q2TJ95 (/IPI) |
Showing 1 to 7 of 7 entries
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
|
4 | Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS) |
|
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
|
4 | Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS) |
|
Positive regulation of non-canonical Wnt signaling pathway GO:2000052
Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
|
4 | Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS) |
|
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
|
3 | Q2MKA7 (/IDA) Q9BXY4 (/IDA) Q9BXY4 (/IDA) |
|
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
|
3 | Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q9Z132 (/ISS) |
|
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
|
3 | Q2MKA7 (/NAS) Q9BXY4 (/NAS) Q9BXY4 (/NAS) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
3 | Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q2TJ95 (/ISS) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | Q2MKA7 (/IDA) Q2TJ95 (/IDA) Q9Z132 (/IDA) |
|
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
|
2 | Q9BXY4 (/TAS) Q9BXY4 (/TAS) |
|
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
|
2 | Q2TJ95 (/ISO) Q9Z132 (/ISO) |
Showing 1 to 10 of 26 entries
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | Q2MKA7 (/NAS) Q9BXY4 (/NAS) Q9BXY4 (/NAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | Q2MKA7 (/TAS) Q9BXY4 (/TAS) Q9BXY4 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q2TJ95 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9Z132 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9Z132 (/IDA) |
Showing 1 to 5 of 5 entries
