The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine Rich Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 68: Insulin gene enhancer protein ISL-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q96A47 (/ISA) Q96A47 (/ISA) Q96A47 (/ISA) Q96A47 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q96A47 (/ISM) Q96A47 (/ISM) Q96A47 (/ISM) Q96A47 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q96A47 (/NAS) Q96A47 (/NAS) Q96A47 (/NAS) Q96A47 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 Q96A47 (/ISS) Q96A47 (/ISS) Q96A47 (/ISS) Q96A47 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9CXV0 (/IPI) Q9CXV0 (/IPI)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
4 Q96A47 (/TAS) Q96A47 (/TAS) Q96A47 (/TAS) Q96A47 (/TAS)
Peripheral nervous system neuron development GO:0048935
The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
4 Q96A47 (/TAS) Q96A47 (/TAS) Q96A47 (/TAS) Q96A47 (/TAS)
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
3 P53406 (/IGI) P53406 (/IGI) P53407 (/IGI)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
2 P53406 (/IGI) P53406 (/IGI)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
2 P53406 (/IMP) P53406 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P53406 (/IMP) P53406 (/IMP)
Spinal cord motor neuron cell fate specification GO:0021520
The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
2 Q9CXV0 (/IGI) Q9CXV0 (/IGI)
Visceral motor neuron differentiation GO:0021524
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 Q9CXV0 (/IGI) Q9CXV0 (/IGI)
Visceral motor neuron differentiation GO:0021524
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 Q9CXV0 (/IMP) Q9CXV0 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
2 Q9CXV0 (/IMP) Q9CXV0 (/IMP)
Angioblast cell migration GO:0035476
The orderly movement of angioblasts, cells involved in blood vessel morphogenesis.
2 P53406 (/IMP) P53406 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 Q9CXV0 (/IGI) Q9CXV0 (/IGI)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 Q9CXV0 (/IMP) Q9CXV0 (/IMP)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
2 Q9CXV0 (/IGI) Q9CXV0 (/IGI)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
2 Q9CXV0 (/IMP) Q9CXV0 (/IMP)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2 P53406 (/IGI) P53406 (/IGI)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2 P53406 (/IMP) P53406 (/IMP)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
2 P53406 (/IMP) P53406 (/IMP)
Venous blood vessel morphogenesis GO:0048845
The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.
2 P53406 (/IMP) P53406 (/IMP)
Secondary heart field specification GO:0003139
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
1 P53407 (/IMP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 P53410 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q96A47 (/IC) Q96A47 (/IC) Q96A47 (/IC) Q96A47 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9CXV0 (/IDA) Q9CXV0 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 P53410 (/IDA)
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