The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 26: PDZ and LIM domain protein 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | O70209 (/IPI) O70400 (/IPI) P36202 (/IPI) P50479 (/IPI) P50479 (/IPI) P52944 (/IPI) P70271 (/IPI) Q53GG5 (/IPI) Q53GG5 (/IPI) Q9PW72 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | A6H7E3 (/ISS) A6H7E3 (/ISS) Q5E9E1 (/ISS) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
3 | P50479 (/IPI) P50479 (/IPI) P70271 (/IPI) |
|
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
|
3 | P36202 (/IPI) P50479 (/IPI) P50479 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Cadherin binding involved in cell-cell adhesion GO:0098641
Any cadherin binding that occurs as part of the process of cell-cell adhesion.
|
2 | O00151 (/HDA) O00151 (/HDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | O70400 (/IDA) |
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O70209 (/IPI) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | O70209 (/IDA) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | O70209 (/TAS) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | P70271 (/ISO) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | Q3T005 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P70271 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q3T005 (/ISS) |
|
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | Q66HS7 (/IDA) |
|
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | P36202 (/IPI) |
|
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | P70271 (/ISO) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q9PW72 (/IDA) |
|
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
|
1 | P70271 (/ISO) |
|
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
|
1 | Q3T005 (/ISS) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Excitatory chemical synaptic transmission GO:0098976
Synaptic transmission that results in an excitatory postsynaptic potential.
|
5 | P50479 (/ISS) P50479 (/ISS) P70271 (/ISS) Q3T005 (/ISS) Q9PW72 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | A6H7E3 (/ISS) A6H7E3 (/ISS) Q5E9E1 (/ISS) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
2 | O00151 (/TAS) O00151 (/TAS) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P52944 (/IEP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O70400 (/IDA) |
|
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
1 | O70209 (/IDA) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | O70209 (/IMP) |
|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P36202 (/IDA) |
|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P70271 (/ISO) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P70271 (/ISO) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q3T005 (/ISS) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | P36202 (/IDA) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | P36202 (/IMP) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | P70271 (/ISO) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
1 | Q9PW72 (/IDA) |
|
Excitatory chemical synaptic transmission GO:0098976
Synaptic transmission that results in an excitatory postsynaptic potential.
|
1 | P36202 (/IDA) |
|
Excitatory chemical synaptic transmission GO:0098976
Synaptic transmission that results in an excitatory postsynaptic potential.
|
1 | P70271 (/ISO) |
There are 42 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Early endosome lumen GO:0031905
The volume enclosed by the membrane of an early endosome.
|
5 | P50479 (/ISS) P50479 (/ISS) P70271 (/ISS) Q3T005 (/ISS) Q9PW72 (/ISS) |
|
Recycling endosome lumen GO:0034777
The volume enclosed by the membranes of a recycling endosome.
|
5 | P50479 (/ISS) P50479 (/ISS) P70271 (/ISS) Q3T005 (/ISS) Q9PW72 (/ISS) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
5 | P50479 (/ISS) P50479 (/ISS) P70271 (/ISS) Q3T005 (/ISS) Q9PW72 (/ISS) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
5 | P50479 (/ISS) P50479 (/ISS) P70271 (/ISS) Q3T005 (/ISS) Q9PW72 (/ISS) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
3 | P36202 (/IDA) P50479 (/IDA) P50479 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | A6H7E3 (/ISS) A6H7E3 (/ISS) Q5E9E1 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P50479 (/IDA) P50479 (/IDA) Q9PW72 (/IDA) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
2 | G3UQT4 (/ISS) Q3T005 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
2 | O00151 (/HDA) O00151 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | O00151 (/HDA) O00151 (/HDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | O70209 (/IPI) P36202 (/IPI) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
2 | G3UQT4 (/ISS) Q3T005 (/ISS) |
|
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P50479 (/IDA) P50479 (/IDA) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | P70271 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P70271 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q3T005 (/ISS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | O70400 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P70271 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3T005 (/ISS) |
|
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | P70271 (/ISO) |
|
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | Q3T005 (/ISS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | G3UQT4 (/ISS) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | P70271 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | G3UQT4 (/ISS) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q66HS7 (/IDA) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | G3UQT4 (/ISS) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | O70209 (/TAS) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | P70271 (/ISO) |
|
Early endosome lumen GO:0031905
The volume enclosed by the membrane of an early endosome.
|
1 | P36202 (/IDA) |
|
Early endosome lumen GO:0031905
The volume enclosed by the membrane of an early endosome.
|
1 | P70271 (/ISO) |
|
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
|
1 | P70271 (/ISO) |
|
Recycling endosome lumen GO:0034777
The volume enclosed by the membranes of a recycling endosome.
|
1 | P36202 (/IDA) |
|
Recycling endosome lumen GO:0034777
The volume enclosed by the membranes of a recycling endosome.
|
1 | P70271 (/ISO) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | P36202 (/IDA) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | P70271 (/ISO) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
1 | P36202 (/IDA) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
1 | P70271 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | P70271 (/ISO) |
