The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 2: LIM domain and actin-binding 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
25 |
O04193 (/IDA)
O04193 (/IDA)
O04193 (/IDA)
O04193 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
Q1ECF5 (/IDA)
Q1ECF5 (/IDA)
(15 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
19 |
Q4U4S6 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
Q7F9R9 (/IPI)
(9 more) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
8 | Q94JX5 (/IDA) Q94JX5 (/IDA) Q94JX5 (/IDA) Q94JX5 (/IDA) Q9M047 (/IDA) Q9M047 (/IDA) Q9M047 (/IDA) Q9M047 (/IDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
2 | Q4U4S6 (/ISO) Q9ERG0 (/ISO) |
|
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | Q9UHB6 (/IDA) |
|
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | Q9ERG0 (/ISO) |
|
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | Q9ERG0 (/ISS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q9UHB6 (/HDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q9ERG0 (/IMP) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q9ERG0 (/ISS) |
|
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
|
1 | Q4U4S6 (/IDA) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
|
25 |
O04193 (/IDA)
O04193 (/IDA)
O04193 (/IDA)
O04193 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
O80839 (/IDA)
Q1ECF5 (/IDA)
Q1ECF5 (/IDA)
(15 more) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
3 | B0KYV5 (/ISS) F1LR10 (/ISS) Q9UHB6 (/ISS) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
3 | B0KYV5 (/ISS) F1LR10 (/ISS) Q9ERG0 (/ISS) |
|
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
|
2 | B0KYV5 (/ISS) Q9UHB6 (/ISS) |
|
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
2 | F1LR10 (/ISS) Q9ERG0 (/ISS) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
2 | B0KYV5 (/ISS) Q9UHB6 (/ISS) |
|
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
|
2 | F1LR10 (/ISS) Q9ERG0 (/ISS) |
|
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
|
1 | Q4U4S6 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q9ERG0 (/IMP) |
|
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
|
1 | Q9ERG0 (/IMP) |
|
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
1 | Q9UHB6 (/IDA) |
|
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
1 | Q9ERG0 (/ISO) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
1 | Q9UHB6 (/IDA) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
1 | Q9ERG0 (/IMP) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
1 | Q9ERG0 (/ISO) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | Q9ERG0 (/IMP) |
|
Cell-cell junction organization GO:0045216
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
|
1 | Q4U4S6 (/IMP) |
|
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
|
1 | Q9ERG0 (/ISO) |
|
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
|
1 | Q4U4S6 (/IMP) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | F8VQE1 (/IDA) F8VS07 (/IDA) Q94JX5 (/IDA) Q94JX5 (/IDA) Q94JX5 (/IDA) Q94JX5 (/IDA) Q9UHB6 (/IDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
4 | F8VQE1 (/IDA) F8VS07 (/IDA) Q9ERG0 (/IDA) Q9UHB6 (/IDA) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
3 | B0KYV5 (/ISS) F1LR10 (/ISS) Q9UHB6 (/ISS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | F8VQE1 (/IDA) F8VS07 (/IDA) Q9UHB6 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | B0KYV5 (/ISS) F1LR10 (/ISS) Q9ERG0 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | F8VQE1 (/IDA) Q9UHB6 (/IDA) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
2 | B0KYV5 (/ISS) Q9UHB6 (/ISS) |
|
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
2 | B0KYV5 (/ISS) Q9ERG0 (/ISS) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q9UHB6 (/IDA) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q9ERG0 (/ISO) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | Q9ERG0 (/ISS) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q9ERG0 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9ERG0 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9ERG0 (/ISO) |
|
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
|
1 | Q9ERG0 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9UHB6 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9ERG0 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q9ERG0 (/ISO) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q4U4S6 (/IDA) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q9ERG0 (/IDA) |
|
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
1 | Q9UHB6 (/IDA) |
|
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
1 | Q9ERG0 (/ISO) |
