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CATH Superfamily 2.10.109.10

Umud Fragment, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Umud Fragment, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35: Signal peptidase I

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Signal peptidase I. [EC: 3.4.21.89]
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
  • Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity.
  • Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein.
  • Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane.
  • Belongs to peptidase family S26.
  • Formerly EC 3.4.99.36.
 13 A0A1W0VMP5 A0A1W0VMP5 A0A1Y3E1M3 A0A1Y3E1M3 A0A1Y3E1M3 A0A2J9KJG7 A0A2J9KJG7 A0A2J9KJG7 O25300 O25300
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