The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Polymerase cofactor VP35

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q05127 (/IPI) Q05127 (/IPI) Q05127 (/IPI) Q05127 (/IPI)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)
Evasion or tolerance by virus of host immune response GO:0030683
Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)
Positive regulation of protein sumoylation GO:0033235
Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
4 Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP)
Suppression by virus of host type I interferon production GO:0039501
Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP)
Suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II GO:0039505
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex.
4 Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP)
Suppression by virus of host protein phosphorylation GO:0039613
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host.
4 Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)
Suppression of host defenses GO:0044414
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP) Q05127 (/IMP)
Suppression by virus of host cytokine production GO:0046775
Any viral process that results in the inhibition of host cell cytokine production.
4 Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)
Negative regulation of gene silencing by miRNA GO:0060965
Any process that decreases the rate, frequency, or extent of gene silencing by miRNA.
4 Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Viral nucleocapsid GO:0019013
The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.
5 P35259 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA) Q05127 (/IDA)
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