The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Mitochondrial carrier domain
".
FunFam 68: Mitochondrial brown fat uncoupling protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Long-chain fatty acid binding GO:0036041
Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(2 more) |
|
Cardiolipin binding GO:1901612
Interacting selectively and non-covalently with cardiolipin.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P12242 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
(2 more) |
|
Oxidative phosphorylation uncoupler activity GO:0017077
Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
|
11 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
Q9GMZ1 (/ISS)
(1 more) |
|
Purine ribonucleotide binding GO:0032555
Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
|
10 | A0PC02 (/ISS) P04575 (/ISS) P04575 (/ISS) P10861 (/ISS) P14271 (/ISS) P25874 (/ISS) Q18P97 (/ISS) Q8K404 (/ISS) Q9ER18 (/ISS) Q9GMZ1 (/ISS) |
|
Oxidative phosphorylation uncoupler activity GO:0017077
Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
|
2 | P04633 (/IDA) P12242 (/IDA) |
|
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
2 | P04633 (/IDA) W5PSH7 (/IDA) |
|
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
|
2 | P25874 (/IDA) W5PSH7 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P12242 (/IPI) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | P04633 (/IDA) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | P12242 (/ISO) |
|
Oxidative phosphorylation uncoupler activity GO:0017077
Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
|
1 | P12242 (/IMP) |
|
Oxidative phosphorylation uncoupler activity GO:0017077
Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
|
1 | P12242 (/ISO) |
|
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
1 | P12242 (/ISO) |
|
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
|
1 | P04633 (/IMP) |
|
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
|
1 | P12242 (/ISO) |
|
Purine ribonucleotide binding GO:0032555
Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
|
1 | P12242 (/IDA) |
|
Long-chain fatty acid binding GO:0036041
Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
|
1 | P12242 (/IDA) |
|
Cardiolipin binding GO:1901612
Interacting selectively and non-covalently with cardiolipin.
|
1 | W5PSH7 (/IDA) |
There are 37 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(2 more) |
|
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(2 more) |
|
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(2 more) |
|
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
|
12 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(2 more) |
|
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
11 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
Q9GMZ1 (/ISS)
(1 more) |
|
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
|
11 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
Q9GMZ1 (/ISS)
(1 more) |
|
Regulation of reactive oxygen species biosynthetic process GO:1903426
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
11 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
Q9GMZ1 (/ISS)
(1 more) |
|
Mitochondrial transmembrane transport GO:1990542
The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
|
10 | A0PC02 (/ISS) P04575 (/ISS) P04575 (/ISS) P10861 (/ISS) P14271 (/ISS) P25874 (/ISS) Q18P97 (/ISS) Q8K404 (/ISS) Q9ER18 (/ISS) Q9GMZ1 (/ISS) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
9 | A0PC02 (/ISS) P04575 (/ISS) P04575 (/ISS) P10861 (/ISS) P14271 (/ISS) Q18P97 (/ISS) Q8K404 (/ISS) Q9ER18 (/ISS) Q9GMZ1 (/ISS) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
4 | P04633 (/IDA) P12242 (/IDA) P25874 (/IDA) W5PSH7 (/IDA) |
|
Mitochondrial transmembrane transport GO:1990542
The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
|
3 | P04633 (/IDA) P12242 (/IDA) W5PSH7 (/IDA) |
|
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
|
2 | P04633 (/IDA) P12242 (/IDA) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | P04633 (/ISS) P25874 (/ISS) |
|
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
|
1 | P12242 (/IMP) |
|
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
|
1 | P04633 (/TAS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P12242 (/IDA) |
|
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
|
1 | P04633 (/IDA) |
|
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
|
1 | P12242 (/ISO) |
|
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
|
1 | P12242 (/IMP) |
|
Positive regulation of metabolic process GO:0009893
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
|
1 | P04633 (/TAS) |
|
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | P12242 (/IMP) |
|
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P04633 (/IEP) |
|
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P12242 (/IMP) |
|
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | P12242 (/IMP) |
|
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
|
1 | P12242 (/IEP) |
|
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
|
1 | P25874 (/ISS) |
|
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
|
1 | P12242 (/ISO) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
1 | P12242 (/IMP) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
1 | P04633 (/IMP) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
1 | P12242 (/ISO) |
|
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
|
1 | P25874 (/TAS) |
|
Regulation of reactive oxygen species biosynthetic process GO:1903426
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
1 | P12242 (/IMP) |
|
Regulation of reactive oxygen species biosynthetic process GO:1903426
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
1 | P04633 (/NAS) |
|
Cellular response to dehydroepiandrosterone GO:1903495
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus.
|
1 | P04633 (/IEP) |
|
Mitochondrial transmembrane transport GO:1990542
The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
|
1 | P12242 (/IMP) |
|
Mitochondrial transmembrane transport GO:1990542
The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
|
1 | P12242 (/ISO) |
|
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
|
1 | P12242 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
11 |
A0PC02 (/ISS)
P04575 (/ISS)
P04575 (/ISS)
P04633 (/ISS)
P10861 (/ISS)
P14271 (/ISS)
P25874 (/ISS)
Q18P97 (/ISS)
Q8K404 (/ISS)
Q9ER18 (/ISS)
(1 more) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P04633 (/IDA) P12242 (/IDA) P25874 (/IDA) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
2 | P12242 (/IDA) W5PSH7 (/IDA) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
2 | P04633 (/TAS) P25874 (/TAS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P12242 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P12242 (/ISO) |
|
Mitochondrial envelope GO:0005740
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
|
1 | P12242 (/IDA) |
