The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Mitochondrial carrier domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Calcium-binding mitochondrial carrier protein Aral...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
7 O75746 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
7 Q21153 (/ISS) Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS) Q9QXX4 (/ISS) Q9VA73 (/ISS)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
7 O75746 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
7 Q21153 (/ISS) Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS) Q9QXX4 (/ISS) Q9VA73 (/ISS)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
5 Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS) Q9QXX4 (/ISS)
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
4 Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 O75746 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O75746 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Uniporter activity GO:0015292
Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species.
3 Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA)
Antiporter activity GO:0015297
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
3 Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA)
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
1 Q9QXX4 (/IMP)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
1 Q9VA73 (/ISS)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartate transmembrane transport GO:0015810
The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.
7 O75746 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
7 O75746 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
5 Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS) Q9QXX4 (/ISS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
4 O75746 (/TAS) Q9UJS0 (/TAS) Q9UJS0 (/TAS) Q9UJS0 (/TAS)
Aspartate transmembrane transport GO:0015810
The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.
4 Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS)
Malate-aspartate shuttle GO:0043490
The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
4 O75746 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Malate-aspartate shuttle GO:0043490
The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
4 A0A0G2K2J7 (/IMP) F1LX07 (/IMP) Q8BH59 (/IMP) Q9QXX4 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
4 O75746 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
4 Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS) Q9QXX4 (/ISS)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
3 Q9UJS0 (/NAS) Q9UJS0 (/NAS) Q9UJS0 (/NAS)
Malate-aspartate shuttle GO:0043490
The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
3 Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS)
Cellular nitrogen compound biosynthetic process GO:0044271
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
3 Q12482 (/IMP) Q12482 (/IMP) Q12482 (/IMP)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
3 Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
2 A0A0G2K2J7 (/IMP) F1LX07 (/IMP)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q5RBC8 (/ISS) Q8HXW2 (/ISS)
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
2 A0A0G2K2J7 (/IMP) F1LX07 (/IMP)
Aspartate transmembrane transport GO:0015810
The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
2 A0A0G2K2J7 (/IMP) F1LX07 (/IMP)
Malate-aspartate shuttle GO:0043490
The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
2 Q5RBC8 (/ISS) Q8HXW2 (/ISS)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Negative regulation of glucose catabolic process to lactate via pyruvate GO:1904024
Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.
2 A0A0G2K2J7 (/IMP) F1LX07 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
2 A0A0G2K2J7 (/IMP) F1LX07 (/IMP)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9QXX4 (/ISO)
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
1 Q9VA73 (/ISS)
Aspartate transmembrane transport GO:0015810
The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.
1 Q9QXX4 (/IMP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q9VA73 (/IMP)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
1 Q9QXX4 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 O75746 (/HDA) Q12482 (/HDA) Q12482 (/HDA) Q12482 (/HDA) Q8BH59 (/HDA) Q9QXX4 (/HDA) Q9VA73 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 O75746 (/IDA) Q8BH59 (/IDA) Q9QXX4 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA) Q9UJS0 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
6 O75746 (/TAS) Q8BH59 (/TAS) Q9QXX4 (/TAS) Q9UJS0 (/TAS) Q9UJS0 (/TAS) Q9UJS0 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q54RB9 (/ISS) Q5RBC8 (/ISS) Q8BH59 (/ISS) Q8HXW2 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
4 Q9UJS0 (/ISS) Q9UJS0 (/ISS) Q9UJS0 (/ISS) Q9VA73 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q9UJS0 (/NAS) Q9UJS0 (/NAS) Q9UJS0 (/NAS)
Vacuole-mitochondrion membrane contact site GO:1990816
A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles.
3 Q12482 (/IDA) Q12482 (/IDA) Q12482 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8BH59 (/IMP) Q9QXX4 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8BH59 (/ISO) Q9QXX4 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 Q8BH59 (/HDA) Q9QXX4 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q5AL11 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O75746 (/NAS)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q8BH59 (/HDA)
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