The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Complement C3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P01024 (/IPI) P01024 (/IPI) P01025 (/IPI) P01026 (/IPI) P01027 (/IPI)
C5L2 anaphylatoxin chemotactic receptor binding GO:0031715
Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Complement binding GO:0001848
Interacting selectively and non-covalently with any component or product of the complement cascade.
3 P98093 (/IDA) Q98977 (/IDA) Q9DDV9 (/IDA)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
3 P98093 (/IDA) Q98977 (/IDA) Q9DDV9 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P01024 (/TAS) P01024 (/TAS)
C5L2 anaphylatoxin chemotactic receptor binding GO:0031715
Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.
2 P01024 (/IDA) P01024 (/IDA)
(1->3)-beta-D-glucan binding GO:0001872
Interacting selectively and non-covalently with (1->3)-beta-D-glucans.
1 P98093 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P01026 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P01027 (/ISO)
C5L2 anaphylatoxin chemotactic receptor binding GO:0031715
Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.
1 P01027 (/ISO)
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
1 P01026 (/IPI)
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
1 P01027 (/ISO)

There are 73 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Regulation of triglyceride biosynthetic process GO:0010866
Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Positive regulation of G protein-coupled receptor signaling pathway GO:0045745
Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
5 P01025 (/ISS) P01026 (/ISS) P01027 (/ISS) P12387 (/ISS) Q2UVX4 (/ISS)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
3 P01024 (/IMP) P01024 (/IMP) P01027 (/IMP)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
3 P01024 (/TAS) P01024 (/TAS) Q90633 (/TAS)
Complement activation, alternative pathway GO:0006957
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
3 P01024 (/TAS) P01024 (/TAS) Q90633 (/TAS)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
3 P01024 (/TAS) P01024 (/TAS) Q90633 (/TAS)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 P98093 (/IDA) Q98977 (/IDA) Q9DDV9 (/IDA)
Activation of membrane attack complex GO:0001905
The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
2 Q98977 (/IDA) Q9DDV9 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 P01024 (/IDA) P01024 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 P01024 (/TAS) P01024 (/TAS)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2 P01026 (/IDA) P01027 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P01024 (/TAS) P01024 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P01024 (/TAS) P01024 (/TAS)
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
2 P01024 (/IDA) P01024 (/IDA)
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P01024 (/IDA) P01024 (/IDA)
Regulation of triglyceride biosynthetic process GO:0010866
Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
2 P01024 (/IDA) P01024 (/IDA)
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
2 P01024 (/IDA) P01024 (/IDA)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
2 P01024 (/ISS) P01024 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P01024 (/TAS) P01024 (/TAS)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
2 P01024 (/TAS) P01024 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
2 P01024 (/TAS) P01024 (/TAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 F1SBS4 (/IDA) P01025 (/IDA)
Positive regulation of G protein-coupled receptor signaling pathway GO:0045745
Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
2 P01024 (/IDA) P01024 (/IDA)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
2 P01024 (/ISS) P01024 (/ISS)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
2 P01024 (/TAS) P01024 (/TAS)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
2 P01024 (/ISS) P01024 (/ISS)
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
2 F1QV29 (/IDA) Q3MU74 (/IDA)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
2 P01024 (/ISS) P01024 (/ISS)
Complement-mediated synapse pruning GO:0150062
Synaptic pruning mediated by complement system signalling.
2 P01024 (/ISS) P01024 (/ISS)
Vertebrate eye-specific patterning GO:0150064
Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus.
2 P01024 (/ISS) P01024 (/ISS)
Positive regulation of apoptotic cell clearance GO:2000427
Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance.
2 P01024 (/IMP) P01024 (/IMP)
Positive regulation of type IIa hypersensitivity GO:0001798
Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
1 P01027 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P01027 (/ISO)
Positive regulation of activation of membrane attack complex GO:0001970
Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
1 P01027 (/IMP)
Tolerance induction GO:0002507
A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
1 P01026 (/IEP)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
1 P01027 (/ISO)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
1 P01026 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P01026 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P01027 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P01027 (/IEP)
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
1 P01027 (/ISO)
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P01027 (/ISO)
Regulation of triglyceride biosynthetic process GO:0010866
Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
1 P01027 (/ISO)
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 P01027 (/ISO)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
1 P01027 (/IMP)
Cytolysis GO:0019835
The rupture of cell membranes and the loss of cytoplasm.
1 Q90633 (/IDA)
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 P01026 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P01026 (/IEP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 P01026 (/IEP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 B8JKW4 (/IMP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 P01026 (/IEP)
Positive regulation of G protein-coupled receptor signaling pathway GO:0045745
Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
1 P01027 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P01027 (/IMP)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 P01027 (/IGI)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 P01027 (/IMP)
Positive regulation of developmental growth GO:0048639
Any process that activates, maintains or increases the rate of developmental growth.
1 P01026 (/IDA)
Positive regulation of developmental growth GO:0048639
Any process that activates, maintains or increases the rate of developmental growth.
1 P01027 (/ISO)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 P01027 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P01026 (/IEP)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 P01027 (/IGI)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 P01027 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P01026 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P01027 (/ISO)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 P01027 (/IGI)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 P01027 (/IMP)
Complement-dependent cytotoxicity GO:0097278
Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complement proteins to that antibody.
1 P01027 (/IMP)
Complement-mediated synapse pruning GO:0150062
Synaptic pruning mediated by complement system signalling.
1 P01027 (/IMP)
Vertebrate eye-specific patterning GO:0150064
Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus.
1 P01027 (/IMP)
Cell surface receptor signaling pathway involved in cell-cell signaling GO:1905114
Any cell surface receptor signaling pathway that is involved in cell-cell signaling.
1 P01027 (/IMP)
Positive regulation of apoptotic cell clearance GO:2000427
Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance.
1 P01027 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P01024 (/IDA) P01024 (/IDA) P01026 (/IDA) Q90633 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P01024 (/TAS) P01024 (/TAS) Q90633 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P01024 (/HDA) P01024 (/HDA) P01027 (/HDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 P01024 (/TAS) P01024 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P01024 (/TAS) P01024 (/TAS)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
2 P01024 (/TAS) P01024 (/TAS)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
2 P01024 (/TAS) P01024 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P01024 (/HDA) P01024 (/HDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
2 P01024 (/HDA) P01024 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P01027 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 P98093 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P01027 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P01027 (/IDA)
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