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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Lupeol synthase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cycloartenol synthase. [EC: 5.4.99.8]
(3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.
    		 2 Q8W3Z3 Q8W3Z4
    Lupeol synthase. [EC: 5.4.99.41]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol.
    • Also forms some beta-amyrin.
    • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
    • See EC 4.2.1.128.
    • Formerly EC 5.4.99.n2.
    		 2 A8CDT3 Q764T8
    Beta-amyrin synthase. [EC: 5.4.99.39]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.
    • Some organism possess a monofunctional beta-amyrin synthase, other have a multifunctional enzyme that also catalyzes the synthesis of alpha-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41).
    • Formerly EC 5.4.99.n1.
    		 2 A8CDT2 Q9LRH7
    Alpha-amyrin synthase. [EC: 5.4.99.40]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.
    • A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39).
    		 1 Q9LRH7
    Camelliol C synthase. [EC: 5.4.99.38]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.
    • The product is 97% camelliol, 2% achilleol A and 0.2% beta-amyrin.
    • Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system.
    • This enzyme probably evolved from EC 5.4.99.39.
    		 1 P0C8Y0
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