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CATH Superfamily 1.50.10.160

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Aphidicolan-16-beta-ol synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Syn-copalyl-diphosphate synthase. [EC: 5.5.1.14]
Geranylgeranyl diphosphate = 9-alpha-copalyl diphosphate.
  • This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B.
  • Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
  • Constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighboring plants).
  • In other tissues the enzyme is up-regulated by conditions that stimulate the biosynthesis of phytoalexins.
 1 Q96WT2
Aphidicolan-16-beta-ol synthase. [EC: 4.2.3.42]
9-alpha-copalyl diphosphate + H(2) = aphidicolan-16-beta-ol + diphosphate.
  • A bifunctional enzyme which also has EC 5.5.1.14 activity.
  • Aphidicolan-16-beta-ol is a precursor of aphidicolin, a specific inhibitor of EC 2.7.7.7.
 1 Q96WT2
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