The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Voltage-dependent anion channel
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Malic acid transporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
12 P0CT95 (/ISO) P0CT95 (/ISO) P0CT95 (/ISO) P0CT95 (/ISO) P0CT96 (/ISO) P0CT96 (/ISO) P0CT96 (/ISO) P0CT96 (/ISO) P0CT97 (/ISO) P0CT97 (/ISO)
(2 more)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
4 P0CT94 (/ISM) P0CT94 (/ISM) P0CT94 (/ISM) P0CT94 (/ISM)
Malate transmembrane transporter activity GO:0015140
Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
1 P50537 (/IMP)
Succinate transmembrane transporter activity GO:0015141
Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.
1 P50537 (/IMP)
Malate:proton symporter activity GO:0015366
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in).
1 P50537 (/IDA)
Malate:proton symporter activity GO:0015366
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in).
1 P50537 (/IMP)
Succinate:proton symporter activity GO:0097434
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in).
1 P50537 (/IDA)
Malonate(1-) transmembrane transporter activity GO:1901239
Enables the transfer of malonate(1-) from one side of a membrane to the other.
1 P50537 (/IMP)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
8 P0CT95 (/ISO) P0CT95 (/ISO) P0CT95 (/ISO) P0CT95 (/ISO) P0CT97 (/ISO) P0CT97 (/ISO) P0CT97 (/ISO) P0CT97 (/ISO)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
4 P0CT94 (/ISM) P0CT94 (/ISM) P0CT94 (/ISM) P0CT94 (/ISM)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q5A3Z6 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5A3Z6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 Q5A3Z6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 Q5A3Z6 (/IMP)
Malate import across plasma membrane GO:0098714
The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol.
1 P50537 (/IDA)
Malate import across plasma membrane GO:0098714
The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol.
1 P50537 (/IMP)
Malonic acid import across plasma membrane GO:0098715
The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol.
1 P50537 (/IMP)
Succinate import across plasma membrane GO:0098720
The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol.
1 P50537 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 P0CT95 (/IC) P0CT95 (/IC) P0CT95 (/IC) P0CT95 (/IC) P0CT96 (/IC) P0CT96 (/IC) P0CT96 (/IC) P0CT96 (/IC) P0CT97 (/IC) P0CT97 (/IC)
(2 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 P0CT94 (/HDA) P0CT94 (/HDA) P0CT94 (/HDA) P0CT94 (/HDA) P50537 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P0CT94 (/ISO) P0CT94 (/ISO) P0CT94 (/ISO) P0CT94 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P0CT94 (/IC) P0CT94 (/IC) P0CT94 (/IC) P0CT94 (/IC)