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CATH Superfamily 1.50.10.130

Terpene synthase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Terpene synthase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Carene synthase, chloroplastic

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(+)-car-3-ene synthase. [EC: 4.2.3.107]
Geranyl diphosphate = (+)-car-3-ene + diphosphate.
  • The enzyme reacts with (3S)-linalyl diphosphate twice as rapidly as geranyl diphosphate, but 25 times as rapidly as (3R)-linalyl diphosphate.
  • It is assumed that (3S)-linalyl diphosphate is normally formed as an enzyme bound intermediate in the reaction.
  • In the reaction the 5-pro-R hydrogen of geranyl diphosphate is eliminated during cyclopropane ring formation.
  • In Picea abies (Norway spruce) and Picea sitchensis (Sitka spruce) terpinolene is also formed.
  • See EC 4.2.3.113.
  • (+)-car-3-ene is associated with resistance of Picea sitchensis (Sitka spruce) to white pine weevil.
 5 C7ASI9 F1CKI6 F1CKI8 F1CKI9 Q84SM8
(+)-alpha-pinene synthase. [EC: 4.2.3.121]
Geranyl diphosphate = (+)-alpha-pinene + diphosphate.
  • Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene.
  • (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate.
  • The 4-pro-R hydrogen of geranyl diphosphate is lost.
  • With synthase II of Pinus taeda (loblolly pine) (+)-beta-pinene was the only product.
  • See also EC 4.2.3.122 and EC 4.2.3.116.
 1 Q84KL3
(-)-alpha-terpineol synthase. [EC: 4.2.3.111]
Geranyl diphosphate + H(2)O = (-)-alpha-terpineol + diphosphate.
  • The enzyme has been characterized from Vitis vinifera (grape).
  • Also forms some 1,8-cineole and traces of other monoterpenoids.
 1 Q84KL4
(-)-alpha-pinene synthase. [EC: 4.2.3.119]
Geranyl-diphosphate = (-)-alpha-pinene + diphosphate.
  • Cyclase II of Salvia officinalis (sage) gives about equal parts (-)- alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids.
  • (3S)-linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate.
  • The 4-pro-S hydrogen of geranyl diphosphate is lost.
  • The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-alpha-pinene and (-)-beta-pinene.
  • However the clone ag11 gave 35% (-)-limonene, 24% (-)-alpha-pinene and 20% (-)-beta-phellandrene.
  • Synthase I from Pinus taeda (loblolly pine) produces (-)-alpha-pinene with traces of (-)-beta-pinene.
  • The enzyme from Picea sitchensis (Sika spruce) forms 70% (-)-alpha- pinene and 30% (-)-beta-pinene.
  • The recombinant PmeTPS1 enzyme from Pseudotsuga menziesii (Douglas fir) gave roughly equal proportions of (-)-alpha-pinene and (-)- camphene plus traces of other monoterpenoids.
  • See also EC 4.2.3.120, EC 4.2.3.117, EC 4.2.3.16 and EC 4.2.3.52.
  • Formerly EC 4.1.99.8, EC 4.2.3.14 and EC 4.2.3.n7.
 1 Q84KL6
Alpha-farnesene synthase. [EC: 4.2.3.46]
(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate.
    		 1 Q84KL5
    (+)-sabinene synthase. [EC: 4.2.3.110]
    Geranyl diphosphate = (+)-sabinene + diphosphate.
    • Isolated from Salvia officinalis (sage).
    • The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids.
    • See EC 4.2.3.114.
    		 1 F1CKJ1