CATH Superfamily 1.50.10.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 15: alpha-1,2-Mannosidase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571
Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
|
3 | M9PG98 (/ISM) O46091 (/ISM) Q7JUF8 (/ISM) |
|
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571
Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
|
2 | F1NAE0 (/IMP) Q9BV94 (/IMP) |
|
Alpha-mannosidase activity GO:0004559
Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
|
1 | Q9FG93 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8BJT9 (/IPI) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
3 | M9PG98 (/IMP) O46091 (/IMP) Q7JUF8 (/IMP) |
|
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
3 | M9PG98 (/IGI) O46091 (/IGI) Q7JUF8 (/IGI) |
|
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
|
3 | M9PG98 (/IGI) O46091 (/IGI) Q7JUF8 (/IGI) |
|
Trimming of terminal mannose on B branch GO:0036509
The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
2 | F1NAE0 (/IMP) Q9BV94 (/IMP) |
|
Ubiquitin-dependent glycoprotein ERAD pathway GO:0097466
An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
|
2 | M9PG98 (/IMP) Q9BV94 (/IMP) |
|
Mannose trimming involved in glycoprotein ERAD pathway GO:1904382
The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD).
|
2 | F1NAE0 (/IMP) Q9BV94 (/IMP) |
|
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
1 | Q9FG93 (/IMP) |
|
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
|
1 | M9PG98 (/IMP) |
|
Trimming of terminal mannose on B branch GO:0036509
The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
1 | Q8BJT9 (/ISO) |
|
Trimming of terminal mannose on B branch GO:0036509
The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
1 | Q9BV94 (/TAS) |
|
Trimming of terminal mannose on C branch GO:0036510
The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
1 | Q9BV94 (/TAS) |
|
Trimming of first mannose on A branch GO:0036511
The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
1 | Q9BV94 (/TAS) |
|
Trimming of second mannose on A branch GO:0036512
The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
|
1 | Q9BV94 (/TAS) |
|
Ubiquitin-dependent glycoprotein ERAD pathway GO:0097466
An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
|
1 | Q8BJT9 (/ISO) |
|
Positive regulation of retrograde protein transport, ER to cytosol GO:1904154
Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.
|
1 | Q8BJT9 (/IDA) |
|
Positive regulation of retrograde protein transport, ER to cytosol GO:1904154
Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.
|
1 | Q9BV94 (/IGI) |
|
Positive regulation of retrograde protein transport, ER to cytosol GO:1904154
Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.
|
1 | Q9BV94 (/IMP) |
|
Positive regulation of retrograde protein transport, ER to cytosol GO:1904154
Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.
|
1 | Q8BJT9 (/ISO) |
|
Mannose trimming involved in glycoprotein ERAD pathway GO:1904382
The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD).
|
1 | Q8BJT9 (/ISO) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | M9PG98 (/IDA) Q9BV94 (/IDA) Q9FG93 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q8BJT9 (/ISO) |
|
Endoplasmic reticulum quality control compartment GO:0044322
A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
|
1 | Q9BV94 (/TAS) |
