The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase, accessory domain (PIK)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Phosphatidylinositol 4-kinase, catalytic, alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
1-phosphatidylinositol 4-kinase activity GO:0004430
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
2 E9Q3L2 (/IMP) E9Q3L2 (/IMP)
1-phosphatidylinositol 4-kinase activity GO:0004430
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
1-phosphatidylinositol 4-kinase activity GO:0004430
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
2 O02811 (/ISS) P42356 (/ISS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
1-phosphatidylinositol 4-kinase activity GO:0004430
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
1 O08662 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P42356 (/IPI)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P42356 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P42356 (/HDA)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
6 E9Q3L2 (/IMP) E9Q3L2 (/IMP) M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Basement membrane organization GO:0071711
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.
4 M9PDM4 (/IMP) Q8MYR7 (/IMP) Q9U1K8 (/IMP) Q9W4X4 (/IMP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Embryonic pectoral fin morphogenesis GO:0035118
The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
2 F1RCP0 (/IMP) Q49GP4 (/IMP)
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Multi-organism membrane organization GO:0044803
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Viral replication complex formation and maintenance GO:0046786
The process of organizing and assembling viral replication proteins in preparation for viral replication.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
2 O02811 (/ISS) P42356 (/ISS)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 P42356 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P42356 (/NAS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P42356 (/IDA)
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
1 P42356 (/IMP)
Multi-organism membrane organization GO:0044803
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism.
1 P42356 (/IMP)
Viral replication complex formation and maintenance GO:0046786
The process of organizing and assembling viral replication proteins in preparation for viral replication.
1 P42356 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 E9Q3L2 (/ISS) E9Q3L2 (/ISS) O02811 (/ISS) O08662 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 E9Q3L2 (/ISS) E9Q3L2 (/ISS) O02811 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Viral replication complex GO:0019034
Specific locations and structures in the virus infected cell involved in replicating the viral genome.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
2 E9Q3L2 (/ISO) E9Q3L2 (/ISO)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
2 O02811 (/ISS) P42356 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P42356 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P42356 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P42356 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P42356 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P42356 (/HDA)
Viral replication complex GO:0019034
Specific locations and structures in the virus infected cell involved in replicating the viral genome.
1 P42356 (/IMP)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
1 O08662 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P42356 (/HDA)
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