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CATH Superfamily 1.25.40.660

Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C

This superfamily comprises the helical subcomplex vacuolar protein sorting-associated protein 35 (Vps35), one of around 50 proteins involved in protein trafficking. Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway PMID:11598206,PMID:25937119. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo PMID:23148298. Mutations in the Vps35 gene have been linked to Parkinson's disease PMID:25416282.

INTERPRO:IPR005378, PFAM:PF03635,DOI:10.1038/nature06216

GO Diversity

Unique GO annotations
86 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1426 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 26
Function
Unique EC:
Unique GO: 86
Taxonomy
Unique Species: 1426