The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoporin, helical domain, central subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Nuclear pore complex subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O75694 (/IPI) O75694 (/IPI) P37199 (/IPI) P38181 (/IPI) P38181 (/IPI) Q9V463 (/IPI)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
3 P38181 (/IGI) P38181 (/IGI) P40064 (/IGI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P38181 (/IMP) P38181 (/IMP)
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
2 O75694 (/TAS) O75694 (/TAS)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
2 P38181 (/IMP) P38181 (/IMP)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P38181 (/IDA) P38181 (/IDA)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 P38181 (/IDA) P38181 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P40064 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9V463 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P40064 (/IDA)

There are 47 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
3 P38181 (/IC) P38181 (/IC) P40064 (/IC)
Protein localization to nuclear inner membrane GO:0036228
A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.
3 P38181 (/IMP) P38181 (/IMP) Q9V463 (/IMP)
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
3 P38181 (/IGI) P38181 (/IGI) P40064 (/IGI)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
2 O75694 (/TAS) O75694 (/TAS)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
2 P38181 (/IMP) P38181 (/IMP)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
2 O75694 (/TAS) O75694 (/TAS)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
2 O75694 (/TAS) O75694 (/TAS)
Nuclear envelope organization GO:0006998
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
2 O75694 (/IDA) O75694 (/IDA)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
2 P38181 (/IMP) P38181 (/IMP)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
2 O75694 (/TAS) O75694 (/TAS)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
2 P38181 (/IMP) P38181 (/IMP)
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
2 P38181 (/IMP) P38181 (/IMP)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2 O75694 (/TAS) O75694 (/TAS)
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
2 O75694 (/TAS) O75694 (/TAS)
Telomere tethering at nuclear periphery GO:0034398
The process in which a telomere is maintained in a specific location at the nuclear periphery.
2 P38181 (/IMP) P38181 (/IMP)
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
2 O75694 (/TAS) O75694 (/TAS)
Heterochromatin assembly involved in chromatin silencing GO:0070869
Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.
2 P38181 (/IMP) P38181 (/IMP)
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
2 O75694 (/TAS) O75694 (/TAS)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
2 O75694 (/TAS) O75694 (/TAS)
Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery GO:0000972
The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.
1 P40064 (/IMP)
Posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery GO:0000973
The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
1 P40064 (/IMP)
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
1 Q9V463 (/IMP)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
1 Q9V463 (/IMP)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
1 Q99P88 (/IMP)
RRNA export from nucleus GO:0006407
The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.
1 Q9URX8 (/ISO)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 Q99P88 (/IMP)
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
1 Q95Y15 (/IMP)
Nuclear envelope organization GO:0006998
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
1 Q99P88 (/ISO)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q9V463 (/IMP)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
1 Q9V463 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q9V463 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9V463 (/IMP)
Growth of a germarium-derived egg chamber GO:0007295
Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.
1 Q9V463 (/IMP)
Cytoplasmic transport, nurse cell to oocyte GO:0007303
The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.
1 Q9V463 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q95Y15 (/IMP)
Oocyte growth in germarium-derived egg chamber GO:0030715
The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster.
1 Q9V463 (/IGI)
Oocyte karyosome formation GO:0030717
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
1 Q9V463 (/IMP)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
1 Q9V463 (/IMP)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
1 Q9V463 (/IMP)
Regulation of nurse cell apoptotic process GO:0045477
Any process that modulates the frequency, rate or extent of nurse cell apoptotic process.
1 Q9V463 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 Q9V463 (/IMP)
Astral spindle assembly involved in male meiosis GO:0055050
The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells.
1 Q9V463 (/IMP)
Atrial cardiac muscle cell action potential GO:0086014
An action potential that occurs in an atrial cardiac muscle cell.
1 Q99P88 (/IMP)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 Q9V463 (/IDA)
Regulation of protein localization to membrane GO:1905475
Any process that modulates the frequency, rate or extent of protein localization to membrane.
1 Q9V463 (/IMP)
Regulation of oogenesis GO:1905879
Any process that modulates the frequency, rate or extent of oogenesis.
1 Q9V463 (/IMP)
Positive regulation of germ cell proliferation GO:1905938
Any process that activates or increases the frequency, rate or extent of germ cell proliferation.
1 Q9V463 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
10 C8V1X8 (/IDA) F1Q953 (/IDA) F1QE76 (/IDA) P38181 (/IDA) P38181 (/IDA) P40064 (/IDA) Q7ZW07 (/IDA) Q95Y15 (/IDA) Q9URX8 (/IDA) Q9V463 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
5 A0A024R071 (/IDA) A0A024R071 (/IDA) E9PF10 (/IDA) O75694 (/IDA) O75694 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4 O75694 (/IDA) O75694 (/IDA) P37199 (/IDA) Q9V463 (/IDA)
Nuclear pore inner ring GO:0044611
A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.
3 P38181 (/IDA) P38181 (/IDA) P40064 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 O75694 (/TAS) O75694 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P37199 (/IDA) Q9V463 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O75694 (/HDA) O75694 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9V463 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q9URX8 (/HDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q99P88 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9URX8 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99P88 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q99P88 (/ISO)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 Q9V463 (/IDA)