The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ankyrin repeat-containing domain
".
FunFam 8: Apoptosis-stimulating of p53 protein 2 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | Q05BL1 (/IPI) Q13625 (/IPI) Q5I1X5 (/IPI) Q5I1X5 (/IPI) Q8WUF5 (/IPI) Q8WUF5 (/IPI) Q96KQ4 (/IPI) |
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
5 | E0AHC9 (/IPI) E0AHD0 (/IPI) E0AHD1 (/IPI) Q13625 (/IPI) Q9XVN3 (/IPI) |
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
|
4 | A0A0B4KF17 (/IDA) Q86BG1 (/IDA) Q86PC3 (/IDA) Q9W2J2 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | Q13625 (/IPI) Q8WUF5 (/IPI) Q8WUF5 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | Q5I1X5 (/ISO) Q5I1X5 (/ISO) Q8CG79 (/ISO) |
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q8WUF5 (/TAS) Q8WUF5 (/TAS) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q8WUF5 (/TAS) Q8WUF5 (/TAS) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q8WUF5 (/HDA) Q8WUF5 (/HDA) |
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
1 | Q8CG79 (/ISO) |
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
1 | Q13625 (/TAS) |
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q13625 (/IPI) |
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q8CG79 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
|
5 | A0A0R4ISD9 (/IMP) F1QWN1 (/IMP) F1R419 (/IMP) Q1LXN7 (/IMP) Q6NSN9 (/IMP) |
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
5 | A0A0R4ISD9 (/IMP) F1QWN1 (/IMP) F1R419 (/IMP) Q1LXN7 (/IMP) Q6NSN9 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | E0AHC9 (/IGI) E0AHD0 (/IGI) E0AHD1 (/IGI) Q9XVN3 (/IGI) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | E0AHC9 (/IMP) E0AHD0 (/IMP) E0AHD1 (/IMP) Q9XVN3 (/IMP) |
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
4 | A0A0B4KF17 (/IGI) Q86BG1 (/IGI) Q86PC3 (/IGI) Q9W2J2 (/IGI) |
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
4 | Q13625 (/TAS) Q8WUF5 (/TAS) Q8WUF5 (/TAS) Q96KQ4 (/TAS) |
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
3 | A0A0G2KB61 (/IMP) D4A6A8 (/IMP) F1M5H6 (/IMP) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Cardiac right ventricle morphogenesis GO:0003215
The process in which the right cardiac ventricle is generated and organized.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Ventricular cardiac muscle tissue development GO:0003229
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
|
2 | F1QWN1 (/IMP) Q1LXN7 (/IMP) |
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Hair cycle GO:0042633
The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
2 | Q13625 (/TAS) Q96KQ4 (/TAS) |
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
|
2 | Q5I1X5 (/ISO) Q5I1X5 (/ISO) |
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
2 | Q13625 (/TAS) Q96KQ4 (/TAS) |
Multicellular organismal homeostasis GO:0048871
Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
2 | Q5I1X5 (/IMP) Q5I1X5 (/IMP) |
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
2 | Q13625 (/IDA) Q96KQ4 (/IDA) |
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
2 | Q62415 (/ISO) Q8CG79 (/ISO) |
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
2 | Q62415 (/ISS) Q8CG79 (/ISS) |
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740
Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway.
|
2 | Q13625 (/TAS) Q96KQ4 (/TAS) |
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
2 | Q62415 (/ISO) Q8CG79 (/ISO) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q13625 (/TAS) |
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | Q8CG79 (/IMP) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q8CG79 (/IMP) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | Q8CG79 (/IGI) |
Response to ionizing radiation GO:0010212
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
|
1 | Q8CG79 (/IMP) |
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
|
1 | F1LW07 (/IMP) |
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
|
1 | Q13625 (/IMP) |
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
|
1 | Q8CG79 (/ISO) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | A0A024R0Q5 (/IDA) A0A024R0Q5 (/IDA) Q13625 (/IDA) Q8WUF5 (/IDA) Q8WUF5 (/IDA) Q96KQ4 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | A0A0G2KB61 (/IDA) D4A6A8 (/IDA) F1M5H6 (/IDA) Q13625 (/IDA) Q96KQ4 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | E0AHC9 (/ISS) E0AHD0 (/ISS) E0AHD1 (/ISS) Q8CG79 (/ISS) Q9XVN3 (/ISS) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
5 | A0A024R0Q5 (/IDA) A0A024R0Q5 (/IDA) Q13625 (/IDA) Q8WUF5 (/IDA) Q8WUF5 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | Q13625 (/TAS) Q8WUF5 (/TAS) Q8WUF5 (/TAS) Q96KQ4 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | Q5I1X5 (/ISO) Q5I1X5 (/ISO) Q62415 (/ISO) Q8CG79 (/ISO) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
4 | A0A0B4KF17 (/IDA) Q86BG1 (/IDA) Q86PC3 (/IDA) Q9W2J2 (/IDA) |
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
|
4 | A0A024R0Q5 (/IDA) A0A024R0Q5 (/IDA) Q8WUF5 (/IDA) Q8WUF5 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | F1QWN1 (/IDA) Q13625 (/IDA) Q1LXN7 (/IDA) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
3 | Q5I1X5 (/ISO) Q5I1X5 (/ISO) Q8CG79 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | A0A0G2KB61 (/IDA) D4A6A8 (/IDA) Q13625 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q62415 (/ISO) Q8CG79 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q62415 (/ISS) Q8CG79 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q8WUF5 (/TAS) Q8WUF5 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q13625 (/TAS) Q96KQ4 (/TAS) |
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
|
2 | Q5I1X5 (/ISO) Q5I1X5 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | Q62415 (/ISO) Q8CG79 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q96KQ4 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q62415 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8CG79 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q96KQ4 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q62415 (/ISO) |