The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ankyrin repeat-containing domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 118: Myotrophin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
59 P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) P62775 (/IPI) Q3T0F7 (/IPI) Q3T0F7 (/IPI)
(49 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q55FM5 (/IDA)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of macromolecule biosynthetic process GO:0010557
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Positive regulation of protein metabolic process GO:0051247
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Regulation of barbed-end actin filament capping GO:2000812
Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.
127 P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62775 (/ISS) P62775 (/ISS)
(117 more)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
119 P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) P62774 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS)
(109 more)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
59 P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP) P58546 (/IMP)
(49 more)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
59 P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS)
(49 more)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
51 P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS)
(41 more)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
51 P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA)
(41 more)
Regulation of striated muscle tissue development GO:0016202
Any process that modulates the frequency, rate or extent of striated muscle development.
51 P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS) P58546 (/NAS)
(41 more)
Regulation of barbed-end actin filament capping GO:2000812
Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.
51 P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA)
(41 more)
Catecholamine metabolic process GO:0006584
The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
8 P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Positive regulation of macromolecule biosynthetic process GO:0010557
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Positive regulation of macromolecule biosynthetic process GO:0010557
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
8 P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
8 P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
8 P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP)
Positive regulation of protein metabolic process GO:0051247
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Positive regulation of protein metabolic process GO:0051247
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
8 P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP) P62775 (/IEP)
Regulation of barbed-end actin filament capping GO:2000812
Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q55FM5 (/IMP)
Negative regulation of barbed-end actin filament capping GO:2000813
Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping.
1 Q55FM5 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
170 P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS) P58546 (/ISS)
(160 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
111 Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS)
(101 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
111 Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS) Q3T0F7 (/ISS)
(101 more)
F-actin capping protein complex GO:0008290
A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
51 P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA) P58546 (/IDA)
(41 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 G9BZS8 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) Q55FM5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
F-actin capping protein complex GO:0008290
A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
8 P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA) P62775 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
8 P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO) P62774 (/ISO)
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