The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Programmed cell death protein 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 O80548 (/IPI) O80548 (/IPI) O80548 (/IPI) O80548 (/IPI) Q53EL6 (/IPI) Q61823 (/IPI) Q8W4Q4 (/IPI) Q8W4Q4 (/IPI) Q8W4Q4 (/IPI) Q8W4Q4 (/IPI)
(8 more)
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
16 O80548 (/IDA) O80548 (/IDA) O80548 (/IDA) O80548 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q94BR1 (/IDA) Q94BR1 (/IDA)
(6 more)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to absence of light GO:0009646
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
16 O80548 (/IEP) O80548 (/IEP) O80548 (/IEP) O80548 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q94BR1 (/IEP) Q94BR1 (/IEP)
(6 more)
Response to carbon starvation GO:0090549
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source.
16 O80548 (/IEP) O80548 (/IEP) O80548 (/IEP) O80548 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q8W4Q4 (/IEP) Q94BR1 (/IEP) Q94BR1 (/IEP)
(6 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 Q53EL6 (/ISS) Q61823 (/ISS) Q98TX3 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Cell aging GO:0007569
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
4 Q61823 (/ISS) Q98TX3 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
4 Q8W4Q4 (/IMP) Q8W4Q4 (/IMP) Q8W4Q4 (/IMP) Q8W4Q4 (/IMP)
Response to ethylene GO:0009723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.
4 Q8W4Q4 (/IMP) Q8W4Q4 (/IMP) Q8W4Q4 (/IMP) Q8W4Q4 (/IMP)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
4 Q53EL6 (/ISS) Q61823 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Atrioventricular valve development GO:0003171
The progression of the atrioventricular valve over time, from its formation to the mature structure.
2 Q1L8Y5 (/IGI) Q7ZVK1 (/IGI)
Atrioventricular valve development GO:0003171
The progression of the atrioventricular valve over time, from its formation to the mature structure.
2 Q1L8Y5 (/IMP) Q7ZVK1 (/IMP)
Positive regulation of smooth muscle cell apoptotic process GO:0034393
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
2 Q9JID1 (/IMP) Q9JID1 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q9JID1 (/IDA) Q9JID1 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q53EL6 (/IDA) Q98TX3 (/IDA)
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
2 Q9JID1 (/IMP) Q9JID1 (/IMP)
Epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast.
2 Q9JID1 (/IGI) Q9JID1 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q53EL6 (/NAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q53EL6 (/TAS)
Cell aging GO:0007569
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
1 Q53EL6 (/IDA)
Cell aging GO:0007569
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
1 Q61823 (/ISO)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q53EL6 (/IDA)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q61823 (/ISO)
Germarium-derived female germ-line cyst formation GO:0030727
Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.
1 Q9VY91 (/IMP)
Positive regulation of smooth muscle cell apoptotic process GO:0034393
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
1 Q61823 (/ISO)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q53EL6 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q61823 (/ISO)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
1 Q98TX3 (/IDA)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q53EL6 (/NAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q61823 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q61823 (/IMP)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q53EL6 (/ISS)
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
1 Q61823 (/ISO)
Epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast.
1 Q61823 (/ISO)
Epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast.
1 Q53EL6 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q61823 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q53EL6 (/ISS)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q61823 (/IMP)
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q53EL6 (/ISS)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q53EL6 (/IMP)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q61823 (/ISO)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 Q53EL6 (/IMP)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 Q61823 (/ISO)
Negative regulation of myofibroblast differentiation GO:1904761
Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation.
1 Q53EL6 (/IMP)
Negative regulation of myofibroblast differentiation GO:1904761
Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation.
1 Q61823 (/ISO)
Negative regulation of vascular smooth muscle cell differentiation GO:1905064
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.
1 Q53EL6 (/IDA)
Negative regulation of vascular smooth muscle cell differentiation GO:1905064
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.
1 Q61823 (/ISO)
Positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
1 Q53EL6 (/IMP)
Positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
1 Q61823 (/ISO)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
1 Q53EL6 (/IMP)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
1 Q61823 (/ISO)
Positive regulation of stem cell differentiation GO:2000738
Any process that activates or increases the frequency, rate or extent of stem cell differentiation.
1 Q9VY91 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 O80548 (/IDA) O80548 (/IDA) O80548 (/IDA) O80548 (/IDA) Q53EL6 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q94BR1 (/IDA)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q53EL6 (/ISS) Q61823 (/ISS) Q98TX3 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q61823 (/ISS) Q98TX3 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA) Q8W4Q4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q61823 (/ISS) Q98TX3 (/ISS) Q9JID1 (/ISS) Q9JID1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9JID1 (/IDA) Q9JID1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q53EL6 (/IMP) Q98TX3 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61823 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q53EL6 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61823 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9VY91 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q61823 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q53EL6 (/TAS)
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