CATH Superfamily 1.25.40.180
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 31: Eukaryotic translation initiation factor 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
GDP-dissociation inhibitor activity GO:0005092
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
GDP-dissociation inhibitor activity GO:0005092
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
|
9 | P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
9 | P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | Q09689 (/ISO) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q09689 (/ISO) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Formation of cytoplasmic translation initiation complex GO:0001732
Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
9 | P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) |
|
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
9 | P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) |
|
Negative regulation of translational initiation GO:0045947
Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
|
9 | P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) P38431 (/IGI) |
|
Negative regulation of translational initiation GO:0045947
Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
|
9 | P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) P38431 (/IMP) |
|
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | Q09689 (/ISO) |
|
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
1 | Q09689 (/ISO) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
|
9 | P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) P38431 (/IPI) |
|
Eukaryotic 48S preinitiation complex GO:0033290
A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
|
9 | P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) P38431 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q09689 (/HDA) |
|
Eukaryotic 48S preinitiation complex GO:0033290
A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
|
1 | Q09689 (/ISO) |
