The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Protein prenylyltransferase
".
FunFam 2: Protein farnesyltransferase/geranylgeranyltransfer...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
4 | P49354 (/IDA) Q04631 (/IDA) Q61239 (/IDA) Q61239 (/IDA) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
4 | P29702 (/ISS) Q04631 (/ISS) Q61239 (/ISS) Q61239 (/ISS) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Rab geranylgeranyltransferase activity GO:0004663
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
|
2 | Q61239 (/IDA) Q61239 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P49354 (/IPI) Q04631 (/IPI) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Acetylcholine receptor regulator activity GO:0030548
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.
|
2 | Q61239 (/IMP) Q61239 (/IMP) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
2 | Q61239 (/IPI) Q61239 (/IPI) |
|
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
1 | P29702 (/ISS) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
1 | P49354 (/TAS) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
1 | P49354 (/IDA) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
1 | P49354 (/TAS) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | P49354 (/IDA) |
|
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | P49354 (/IDA) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
4 | P29702 (/ISS) Q04631 (/ISS) Q61239 (/ISS) Q61239 (/ISS) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
4 | P29702 (/ISS) Q04631 (/ISS) Q61239 (/ISS) Q61239 (/ISS) |
|
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
2 | Q541Z2 (/IMP) Q541Z2 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Neurotransmitter receptor metabolic process GO:0045213
The chemical reactions and pathways involving neurotransmitter receptors.
|
2 | Q61239 (/IMP) Q61239 (/IMP) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Skeletal muscle acetylcholine-gated channel clustering GO:0071340
The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
|
2 | Q541Z2 (/IDA) Q541Z2 (/IDA) |
|
Positive regulation of tubulin deacetylation GO:0090044
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Positive regulation of deacetylase activity GO:0090045
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P49354 (/TAS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q04631 (/IMP) |
|
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
|
1 | Q04631 (/IMP) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | Q04631 (/IMP) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
1 | P49354 (/IDA) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
1 | P49354 (/TAS) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | P49354 (/IDA) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | P49354 (/TAS) |
|
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
|
1 | P49354 (/TAS) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | Q04631 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q04631 (/IMP) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
1 | Q04631 (/IMP) |
|
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
|
1 | Q04631 (/IMP) |
|
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
|
1 | Q04631 (/IMP) |
|
Positive regulation of tubulin deacetylation GO:0090044
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
|
1 | P49354 (/IDA) |
|
Positive regulation of deacetylase activity GO:0090045
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
1 | P49354 (/IDA) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
4 | P29702 (/ISS) Q04631 (/ISS) Q61239 (/ISS) Q61239 (/ISS) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
3 | P29702 (/ISS) Q61239 (/ISS) Q61239 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
2 | P49354 (/IDA) Q04631 (/IDA) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
2 | Q61239 (/ISO) Q61239 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q04631 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P49354 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P49354 (/TAS) |
|
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
1 | P49354 (/IDA) |
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
1 | P49354 (/IDA) |
