The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Pumilio homolog 1 isoform 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
12 Q07807 (/IDA) Q388X7 (/IDA) Q388X7 (/IDA) Q389G5 (/IDA) Q389G5 (/IDA) Q9C5E7 (/IDA) Q9LJX4 (/IDA) Q9SS47 (/IDA) Q9SS47 (/IDA) Q9ZW02 (/IDA)
(2 more)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
11 P25822 (/IDA) P25822 (/IDA) Q09487 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q80U78 (/IDA) Q8TB72 (/IDA)
(1 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q80U58 (/IDA) Q8TB72 (/IDA) Q9ZW06 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q14671 (/IPI) Q14671 (/IPI) Q14671 (/IPI) Q14671 (/IPI) Q14671 (/IPI) Q80U58 (/IPI) Q8TB72 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
6 Q14671 (/HDA) Q14671 (/HDA) Q14671 (/HDA) Q14671 (/HDA) Q14671 (/HDA) Q8TB72 (/HDA)
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
6 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q8TB72 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 Q388X7 (/ISM) Q388X7 (/ISM) Q389G5 (/ISM) Q389G5 (/ISM)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
4 Q23191 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
2 P25822 (/IDA) P25822 (/IDA)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
2 P25822 (/TAS) P25822 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P25822 (/IPI) P25822 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q80U58 (/ISO) Q80U78 (/ISO)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
2 Q80U58 (/ISO) Q80U78 (/ISO)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
2 P25822 (/TAS) P25822 (/TAS)
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
1 Q9LJX4 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q07807 (/HDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q54WA7 (/IMP)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 O94462 (/ISO)
Exoribonuclease activator activity GO:0044692
Binds to and increases the activity of an exoribonuclease.
1 O94462 (/IDA)
CCR4-NOT complex binding GO:1905762
Interacting selectively and non-covalently with a CCR4-NOT complex.
1 O94462 (/IDA)

There are 80 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
10 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q388X7 (/IDA) Q388X7 (/IDA) Q389G5 (/IDA) Q389G5 (/IDA) Q8TB72 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
8 Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
8 Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
8 Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q80U58 (/IMP) Q80U78 (/IMP) Q8TB72 (/IMP)
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
8 Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
8 Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
8 Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q14671 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
6 Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q14671 (/IMP) Q8TB72 (/IMP)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
6 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q8TB72 (/IDA)
Regulation of chromosome segregation GO:0051983
Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
6 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q8TB72 (/IDA)
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
6 Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS) Q8TB72 (/TAS)
Positive regulation of RIG-I signaling pathway GO:1900246
Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.
6 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q8TB72 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
5 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
5 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA)
MRNA metabolic process GO:0016071
The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
4 Q388X7 (/ISM) Q388X7 (/ISM) Q389G5 (/ISM) Q389G5 (/ISM)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
4 Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS) Q80U78 (/ISS)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
4 Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS) Q80U78 (/ISS)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
3 Q5R5X3 (/ISS) Q80U58 (/ISS) Q80U78 (/ISS)
Regulation of chromosome segregation GO:0051983
Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
3 Q5R5X3 (/ISS) Q80U58 (/ISS) Q80U78 (/ISS)
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
3 O94462 (/IDA) P25822 (/IDA) P25822 (/IDA)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
2 P25822 (/TAS) P25822 (/TAS)
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288
A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
2 P25822 (/TAS) P25822 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 A0A1D8PMA5 (/IMP) Q07807 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 P25822 (/IMP) P25822 (/IMP)
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
2 P25822 (/IMP) P25822 (/IMP)
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
2 P25822 (/TAS) P25822 (/TAS)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
2 P25822 (/TAS) P25822 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q09487 (/IMP) Q80U78 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 P25822 (/IMP) P25822 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 P25822 (/TAS) P25822 (/TAS)
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
2 P25822 (/IMP) P25822 (/IMP)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
2 P25822 (/IDA) P25822 (/IDA)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
2 P25822 (/TAS) P25822 (/TAS)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
2 Q5R5X3 (/ISS) Q80U58 (/ISS)
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
2 P25822 (/IDA) P25822 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 P25822 (/TAS) P25822 (/TAS)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 P25822 (/TAS) P25822 (/TAS)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2 P25822 (/IMP) P25822 (/IMP)
Germ-line stem cell division GO:0042078
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
2 P25822 (/NAS) P25822 (/NAS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 Q5R5X3 (/ISS) Q80U58 (/ISS)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 P25822 (/TAS) P25822 (/TAS)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
2 P25822 (/TAS) P25822 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P25822 (/TAS) P25822 (/TAS)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
2 P25822 (/IMP) P25822 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
2 P25822 (/TAS) P25822 (/TAS)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 P25822 (/IMP) P25822 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
2 P25822 (/IMP) P25822 (/IMP)
Regulation of chromosome segregation GO:0051983
Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Positive regulation of RIG-I signaling pathway GO:1900246
Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288
A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
1 Q07807 (/IMP)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
1 Q07807 (/IDA)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q23191 (/ISS)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q09487 (/TAS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 Q9LJX4 (/IMP)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
1 Q09487 (/IMP)
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
1 Q07807 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 Q80U78 (/IMP)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
1 Q07807 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q9LJX4 (/IMP)
Drought recovery GO:0009819
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition.
1 Q9LJX4 (/IMP)
Regulation of ubiquinone biosynthetic process GO:0010795
Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
1 Q07807 (/IMP)
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
1 Q80U78 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q54WA7 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q23191 (/ISS)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q54WA7 (/IMP)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
1 Q80U58 (/IDA)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
1 Q09487 (/IGI)
Regulation of mitochondrial mRNA stability GO:0044528
Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.
1 A0A1D8PMA5 (/IMP)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q07807 (/IMP)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
1 Q80U78 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q9LJX4 (/IMP)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
1 Q07807 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q80U78 (/ISO)
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
1 Q80U78 (/IDA)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
1 Q9LJX4 (/IMP)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 Q8TB72 (/IMP)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
29 A0A0A0MR59 (/IDA) A0A0C4DG68 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA)
(19 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
24 E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA)
(14 more)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
24 E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA) E9PR38 (/IDA)
(14 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
10 H0YEH2 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q5T1Z4 (/IDA) Q5T1Z4 (/IDA) Q5T1Z4 (/IDA) Q5T1Z8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P25822 (/IDA) P25822 (/IDA) Q07807 (/IDA) Q388X7 (/IDA) Q388X7 (/IDA) Q389G5 (/IDA) Q389G5 (/IDA) Q80U78 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
7 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q80U58 (/IDA) Q8TB72 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
5 Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA) Q14671 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS) Q14671 (/TAS)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
4 Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS) Q80U78 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q23191 (/ISS) Q2VB19 (/ISS) Q2VB19 (/ISS) Q5R5X3 (/ISS)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
3 A0A0A0MR59 (/IDA) A0A0C4DG68 (/IDA) Q8TB72 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 P25822 (/IDA) P25822 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P25822 (/HDA) P25822 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q4Q475 (/ISO) Q4QDP7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
2 Q80U58 (/ISO) Q80U78 (/ISO)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 P25822 (/IDA) P25822 (/IDA)
Type Ib terminal bouton GO:0061176
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons.
2 P25822 (/IDA) P25822 (/IDA)
Type Is terminal bouton GO:0061177
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons.
2 P25822 (/IDA) P25822 (/IDA)
Neuronal ribonucleoprotein granule GO:0071598
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
2 P25822 (/IDA) P25822 (/IDA)
Muscle cell postsynaptic specialization GO:0097482
A postsynaptic specialization that is part of a neuromuscular junction.
2 P25822 (/IDA) P25822 (/IDA)
Messenger ribonucleoprotein complex GO:1990124
A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
2 P25822 (/IDA) P25822 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
1 Q80U78 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80U78 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q80U78 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 Q9LJX4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94462 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9ZW02 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 Q8TB72 (/ISS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q80U78 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q80U58 (/ISO)
Cytoplasmic side of mitochondrial outer membrane GO:0032473
The external (cytoplasmic) face of the mitochondrial outer membrane.
1 Q07807 (/IDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 Q09487 (/IDA)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
1 Q09487 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8TB72 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q80U58 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q80U58 (/ISS)
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